A kinetic study of lung DNA-synthesis during simulated chronic high altitude hypoxia.

Thorax ·Vol. 32 ·No. 5 ·1977-10-00 ·Pages 578-81

Völkel N, Wiegers U, Sill V, Trautmann J

Abstract

Rats were exposed to crhonic hypobaric hypoxia at a simulated altitude of 4250 m for 3, 6, 9, 12, 20, and 35 days. The in-vitro incorporation of 3H-thymidine into the DNA of lung tissue was measured and compared with that of normoxic controls: the obtained time course study showed a maximum increase of 345% on the ninth day of hypoxia, indicating a marked stimulation of cellular proliferation. Between the 12th and 20th day of hypoxia, the lung DNA-synthesis reached control values. No significant change in the DNA-concentration of the lungs was registered. The response to hypoxia was less impressive in rat livers used as controls.

MeSH Terms

Altitude Sickness/metabolism Animals Chronic Disease DNA/biosynthesis Female Hypoxia/metabolism Liver/metabolism Lung/metabolism Rats Time Factors

Chemicals

DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Völkel N

Wiegers U

Sill V

Trautmann J

References (12)

12 references, click to expand

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Article Info

Journal

Thorax

Abbr.

Thorax

ISSN

0040-6376

DOI

10.1136/thx.32.5.578

Published

1977-10-00

Pages

578-81

Language

English

Region

England

NLM ID

0417353

PMCID

PMC470793

Subset

External Links

PubMed source DOI: 10.1136/thx.32.5.578 PMC Full Text View journal details

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A kinetic study of lung DNA-synthesis during simulated chronic high altitude hypoxia.

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