A possible route to the production of free L-tyrosine O-sulphate by the rat.
1. l-Tyrosylglycine O[(35)S]-sulphate is metabolized by the rat to yield the O[(35)S]-sulphate esters of l-tyrosine, p-hydroxyphenylpyruvic acid and p-hydroxyphenylacetic acid. 2. The proportion of the administered peptide which is excreted as l-tyrosine O[(35)S]-sulphate is greater at a higher dose. 3. An enzyme capable of hydrolysing the peptide bond of l-tyrosylglycine O[(35)S]-sulphate to yield l-tyrosine O[(35)S]-sulphate has been detected in rat liver and kidney. 4. The activity of this enzyme is completely inhibited by a large excess of l-tyrosylglycine.
12 references, click to expand
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TYROSINE O-SULPHATE IN FIBRINOGEN AND FIBRIN.Biochem J. 1963 Dec;89:621-4 PMID: 14101983
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AMINO-ACID SEQUENCE INVESTIGATIONS OF FIBRINOPEPTIDES FROM VARIOUS MAMMALS: EVOLUTIONARY IMPLICATIONS.Nature. 1964 Apr 11;202:147-52 PMID: 14156289
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A rat-tissue aminotransferase acting on L-tyrosine O-sulphate.Biochem J. 1966 Jan;98(1):168-72 PMID: 4287183
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Studies on L-tyrosine O-sulphate. 3. The metabolic fate of the L-tyrosine O[35S]-sulphate residue of 35S-labelled rabbit fibrinopeptide B.Biochem J. 1963 Jun;87:548-53 PMID: 14041998
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BIOSYNTHESIS OF L-TYROSINE O-SULPHATE FROM THE METHYL AND ETHYL ESTERS OF L-TYROSINE.Biochem J. 1965 Feb;94:331-6 PMID: 14348193
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On the [35S]sulphate incorporation in fibrinopeptide B from rabbit fibrinogen.Biochim Biophys Acta. 1960 Mar 11;38:502-12 PMID: 13849080
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THE ANTRAL HORMONE GASTRIN. STRUCTURE OF GASTRIN.Nature. 1964 Dec 5;204:931-3 PMID: 14248711
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Studies on sulphatases. 23. The enzymic desulphation of tyrosine O-sulphate.Biochem J. 1959 Jan;71(1):10-5 PMID: 13628524
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Observations on the metabolism of tyrosine O[35S]-sulphate in the rat.Biochem J. 1961 May;79:209-13 PMID: 13723348
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Studies on l-tyrosine O-sulphate. 2. Identification of p-hydroxyphenylpyruvic acid [S]sulphate as a metabolite of l-tyrosine O[S]-sulphate in the rat.Biochem J. 1963 Jun;87(3):545-8 PMID: 16749016
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The biological sulphation of L-tyrosyl peptides.Biochem J. 1966 Jan;98(1):138-41 PMID: 5938633
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The metabolism of exogenous N-acetyl-d-glucosamine 6-O[S]-sulphate in the normal rat.Biochem J. 1961 Sep;80(3):572-8 PMID: 16748925
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