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PMID: 6028492 Published · ppublish English Journal Article

Studies on the pathogenesis of fever. XV. The production of endogenous pyrogen by peritoneal macrophages.

The Journal of experimental medicine ·Vol. 126 ·No. 2 ·1967-08-01 ·Pages 385-94

Hahn HH, Char DC, Postel WB, Wood WB

Abstract

Macrophages from oil-induced peritoneal exudates in rabbits produce endogenous pyrogen when first activated by incubation in 4 hr exudate fluid and then stimulated by incubation in potassium-free isotonic sodium chloride solution. The failure of earlier investigators to obtain pyrogen from macrophages is explained, and the relevance of macrophage pyrogen to fevers of agranulocytosis and other diseases, in which mononuclear rather than granulocytic exudates predominate, is discussed.

MeSH Terms
Animals Culture Techniques Cytoplasmic Granules/metabolism Exudates and Transudates/chemically induced Fever/etiology Injections, Intraperitoneal Isotonic Solutions/pharmacology Macrophages/metabolism Mineral Oil Peritoneum/metabolism Pyrogens/biosynthesis Rabbits
Chemicals
Isotonic Solutions Pyrogens Mineral Oil
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hahn H H
Char D C
Postel W B
Wood W B
References (22)
22 references, click to expand
  1. Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen.
    J Exp Med. 1963 Mar 1;117:349-64 PMID: 14014022
  2. Studies on the pathogenesis of fever. XIV. Further observations on the chemistry of leukocytic pyrogen.
    J Exp Med. 1966 Mar 1;123(3):433-44 PMID: 5937057
  3. Molecular mechanisms involved in the release of pyrogen from polymorphonuclear leucocytes.
    Trans Assoc Am Physicians. 1962;75:190-7 PMID: 13970889
  4. Absence of endotoxic activity in materials derived without bacterial contamination from mammalian tissue.
    Proc Soc Exp Biol Med. 1960 Dec;105:443-5 PMID: 13769678
  5. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.
    J Exp Med. 1953 Nov;98(5):493-508 PMID: 13109105
  6. Human leukocyte pyrogen producing fever in rabbits.
    Proc Soc Exp Biol Med. 1966 Mar;121(3):943-6 PMID: 5935620
  7. Studies on the pathogenesis of fever. III. Failure to demonstrate fever-producing substances in the tissues of leukopenic rabbits.
    Bull Johns Hopkins Hosp. 1956 Jan;98(1):1-6 PMID: 13276717
  8. Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits.
    J Exp Med. 1953 Nov;98(5):477-92 PMID: 13109104
  9. THE FUNDAMENTAL PROPERTIES OF THE FIBROBLAST AND THE MACROPHAGE : II. THE MACROPHAGE.
    J Exp Med. 1926 Aug 31;44(3):285-305 PMID: 19869185
  10. Studies on the pathogenesis of fever. IV. The site of action of leucocytic and circulating endogenous pyrogen.
    J Exp Med. 1958 Feb 1;107(2):291-303 PMID: 13491763
  11. Studies on the pathogenesis of fever. III. The leucocytic origin of endogenous pyrogen in acute inflammatory exudates.
    J Exp Med. 1958 Feb 1;107(2):279-89 PMID: 13491762
  12. THE PRESENCE OF ENDOGENOUS PYROGEN IN NORMAL RABBIT TISSUES.
    J Exp Med. 1965 Jun 1;121:1019-38 PMID: 14319400
  13. Some humoral aspects of the development of tolerance to bacterial pyrogens in rabbits.
    Am J Physiol. 1954 May;177(2):269-78 PMID: 13158559
  14. Similarity of host responses elicited by polysaccharides of animal and plant origin and by bacterial endotoxins.
    J Exp Med. 1957 Jul 1;106(1):77-97 PMID: 13439117
  15. A study of the liberation of pyrogen by hypersensitive cells on incubation in vitro with specific antigen.
    J Pathol Bacteriol. 1965 Jul;90(1):115-22 PMID: 5843932
  16. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.
    J Exp Med. 1955 Nov 1;102(5):499-516 PMID: 13271667
  17. STUDIES ON TUBERCULIN FEVER. 3. MECHANISMS INVOLVED IN THE RELEASE OF ENDOGENOUS PYROGEN IN VITRO.
    J Exp Med. 1965 Aug 1;122:207-35 PMID: 14316942
  18. Studies on the pathogensis of fever. IX. The production of endogenous pyrogen by polymorphonuclear leucocytes.
    J Exp Med. 1962 Jan 1;115:27-36 PMID: 14453159
  19. Release of an endogenous pyrogen in vitro from rabbit mononuclear cells.
    J Exp Med. 1967 Aug 1;126(2):357-84 PMID: 6028491
  20. Studies on the pathogenesis of fever. VI. The interaction of leucocytes and endotoxin in vitro.
    J Exp Med. 1959 Dec 1;110:1005-16 PMID: 13811296
  21. STUDIES ON THE PATHOGENESIS OF FEVER. 13. THE EFFECT OF PHAGOCYTOSIS ON THE RELEASE OF ENDOGENOUS PYROGEN BY POLYMORPHONUCLEAR LEUKOCYTES.
    J Exp Med. 1964 May 1;119:715-26 PMID: 14157026
  22. Release of endogenous pyrogen by human monocytes.
    N Engl J Med. 1967 May 4;276(18):1002-8 PMID: 5228572
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.126.2.385
Published
1967-08-01
Pages
385-94
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2138324
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.126.2.385 PMC Full Text View journal details
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