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PMID: 6067329 Published · ppublish English Journal Article

Inhibition by actinomycin D of uridine diphosphoglucose synthetase activity during differentiation of Dictyostelium discoideum.

Journal of bacteriology ·Vol. 93 ·No. 6 ·1967-06-00 ·Pages 1762-4

Wright B, Pannbacker R

Abstract

Actinomycin D inhibits the increase in specific activity of uridine diphosphoglucose synthetase during differentiation of the cellular slime mold, Dictyostelium discoideum. The degree to which this inhibition occurs is strictly correlated with, and may result from, the general inhibition of morphogenesis by actinomycin D.

MeSH Terms
Cell Differentiation/drug effects Dactinomycin/pharmacology Ligases/metabolism Myxomycetes/drug effects,enzymology,growth & development
Chemicals
Dactinomycin Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wright B
Pannbacker R
References (11)
11 references, click to expand
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  2. Actinomycin D: inhibition of protein synthesis unrelated to effect on template RNA synthesis.
    Science. 1965 Sep 24;149(3691):1504-6 PMID: 5890452
  3. ON ENZYME-SUBSTRATE RELATIONSHIPS DURING BIOCHEMICAL DIFFERENTIATION.
    Proc Natl Acad Sci U S A. 1960 Jun;46(6):798-803 PMID: 16590674
  4. Uridyl transferases and the formation of uridine triphosphate; enzymic production of uridine triphosphate: uridine diphosphoglucose pyrophosphorolysis.
    Nature. 1953 Dec 5;172(4388):1036-7 PMID: 13111246
  5. Action of actinomycin D on animal cells and viruses.
    Proc Natl Acad Sci U S A. 1962 Jul 15;48:1238-45 PMID: 14491128
  6. The effect of actinomycin D on development in the cellular slime mold.
    Biochem Biophys Res Commun. 1966 Aug 12;24(3):334-9 PMID: 6007711
  7. Inactive alkaline phosphatase in duodenum of nursling mouse: immunological evidence.
    Science. 1966 Nov 25;154(3752):1037-8 PMID: 5919756
  8. RNA METABOLISM OF B. SUBTILIS. EFFECTS OF ACTINOMYCIN.
    Biochim Biophys Acta. 1963 Sep 17;76:68-79 PMID: 14068562
  9. The regulatory program for UDPgalactose polysaccharide transferase activity during slime mold cytodifferentiation: requirement for specific synthesis of ribonucleic acid.
    Biochim Biophys Acta. 1965 Nov 8;108(3):463-73 PMID: 5867535
  10. ACTINOMYCIN D: AN EFFECT ON RAT LIVER HOMOGENATES UNRELATED TO ITS ACTION ON RNA SYNTHESIS.
    Science. 1964 Dec 4;146(3649):1311-3 PMID: 14207459
  11. Actinomycin D: inhibition of respiration and glycolysis.
    Science. 1966 Feb 25;151(3713):1007-10 PMID: 5907287
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.93.6.1762-1764.1967
Published
1967-06-00
Pages
1762-4
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC276689
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.93.6.1762-1764.1967 PMC Full Text View journal details
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