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PMID: 6088582 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells.

The Journal of clinical investigation ·Vol. 74 ·No. 3 ·1984-09-00 ·Pages 669-76

Deuel TF, Huang JS

Abstract

暂无摘要

MeSH Terms
Amino Acid Sequence Animals Blood Platelets/physiology Cell Transformation, Neoplastic Cell Transformation, Viral Genes Genes, Viral Humans Mitogens Platelet-Derived Growth Factor/genetics,physiology Protein Kinases/metabolism Protein-Tyrosine Kinases Receptors, Cell Surface/physiology Receptors, Platelet-Derived Growth Factor Sarcoma Virus, Woolly Monkey/genetics Wound Healing
Chemicals
Mitogens Platelet-Derived Growth Factor Receptors, Cell Surface Protein Kinases Protein-Tyrosine Kinases Receptors, Platelet-Derived Growth Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Deuel T F
Huang J S
References (84)
84 references, click to expand
  1. Platelet-derived growth factor in chemotactic for fibroblasts.
    J Cell Biol. 1982 Feb;92(2):584-8 PMID: 7061598
  2. Growth factors adherent to cell substrate are mitogenically active in situ.
    Nature. 1982 Mar 11;296(5853):154-6 PMID: 6278315
  3. Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7314-7 PMID: 6950377
  4. Interaction of platelet-derived growth factor with its fibroblast receptor. Demonstration of ligand degradation and receptor modulation.
    J Biol Chem. 1982 Apr 25;257(8):4216-21 PMID: 6279627
  5. Platelet-derived growth factor. I. High yield purification and evidence for multiple forms.
    J Biol Chem. 1982 May 10;257(9):5154-60 PMID: 7068680
  6. Platelet-derived growth factor. II. Specific binding to cultured cells.
    J Biol Chem. 1982 May 10;257(9):5161-71 PMID: 6279659
  7. Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.
    J Clin Invest. 1982 Apr;69(4):1046-9 PMID: 7076844
  8. Platelet-derived growth factor. Specific binding to target cells.
    J Biol Chem. 1982 Jul 25;257(14):8130-6 PMID: 6282873
  9. Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.
    Proc Natl Acad Sci U S A. 1982 Apr;79(8):2490-4 PMID: 6283530
  10. Human platelet-derived growth factor stimulates amino acid transport and protein synthesis by human diploid fibroblasts in plasma-free media.
    Proc Natl Acad Sci U S A. 1982 May;79(10):3203-7 PMID: 6954470
  11. Platelet-derived growth factor binds specifically to receptors on vascular smooth muscle cells and the binding becomes nondissociable.
    Proc Natl Acad Sci U S A. 1982 Oct;79(19):5867-70 PMID: 6310551
  12. Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells.
    Science. 1983 Sep 30;221(4618):1348-50 PMID: 6310754
  13. Cellular oncogenes and retroviruses.
    Annu Rev Biochem. 1983;52:301-54 PMID: 6351725
  14. Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor.
    Nature. 1983 Oct 13-19;305(5935):605-8 PMID: 6312326
  15. Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants.
    J Clin Invest. 1983 Nov;72(5):1759-63 PMID: 6630524
  16. Cellular oncogenes and multistep carcinogenesis.
    Science. 1983 Nov 18;222(4625):771-8 PMID: 6356358
  17. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.
    Cell. 1983 Dec;35(3 Pt 2):603-10 PMID: 6606489
  18. Synthesis of a PDGF-like growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus.
    Biochem Biophys Res Commun. 1983 Nov 30;117(1):176-82 PMID: 6318746
  19. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.
    Nature. 1984 Feb 9-15;307(5951):521-7 PMID: 6320011
  20. Specific covalent binding of platelet-derived growth factor to human plasma alpha 2-macroglobulin.
    Proc Natl Acad Sci U S A. 1984 Jan;81(2):342-6 PMID: 6198647
  21. An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates.
    Cell. 1979 Dec;18(4):925-33 PMID: 229973
  22. Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine.
    Nature. 1980 Feb 28;283(5750):826-31 PMID: 6244493
  23. Serum stimulation of phospholipase A2 and prostaglandin release in 3T3 cells is associated with platelet-derived growth-promoting activity.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):137-41 PMID: 6928609
  24. Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.
    J Biol Chem. 1980 May 25;255(10):4834-42 PMID: 6246084
  25. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1311-5 PMID: 6246487
  26. Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins.
    Curr Top Microbiol Immunol. 1983;107:125-61 PMID: 6421545
  27. Platelet-derived growth factor: purification, properties, and biological activities.
    Prog Hematol. 1983;13:201-21 PMID: 6322229
  28. Transformation of NIH 3T3 cells by a human c-sis cDNA clone.
    Nature. 1984 Mar 29-Apr 4;308(5958):464-7 PMID: 6323994
  29. Expression of cellular oncogenes in human malignancies.
    Science. 1984 Apr 20;224(4646):256-62 PMID: 6538699
  30. The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.
    EMBO J. 1984 May;3(5):921-8 PMID: 6329745
  31. Chromosomal consitution of meningiomas.
    Nature. 1967 Oct 7;216(5110):84-5 PMID: 6050684
  32. The fibroblast and wound repair.
    Biol Rev Camb Philos Soc. 1968 Feb;43(1):51-96 PMID: 4229841
  33. Calcium as a regulator of the proliferation of normal, but not of transformed, chicken fibroblasts in a plasma-containing medium.
    Proc Natl Acad Sci U S A. 1971 Feb;68(2):271-5 PMID: 5277067
  34. Roles of calcium, serum, plasma, and folic acid in the control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts.
    Proc Natl Acad Sci U S A. 1973 Mar;70(3):675-9 PMID: 4351800
  35. The response of cultured human normal glial cells to growth factors.
    Adv Metab Disord. 1975;8:85-100 PMID: 1106160
  36. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse.
    Nature. 1982 Oct 14;299(5884):640-4 PMID: 6289129
  37. Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.
    Proc Natl Acad Sci U S A. 1982 Jul;79(14):4303-7 PMID: 6181505
  38. Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.
    Proc Natl Acad Sci U S A. 1982 Aug;79(15):4691-5 PMID: 6289313
  39. Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.
    Science. 1982 Nov 12;218(4573):686-8 PMID: 6291150
  40. Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.
    Proc Natl Acad Sci U S A. 1983 Feb;80(3):731-5 PMID: 6298772
  41. Chemotactic activity of platelet alpha granule proteins for fibroblasts.
    J Cell Biol. 1983 Feb;96(2):382-5 PMID: 6187750
  42. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
    Science. 1983 Jul 15;221(4607):275-7 PMID: 6304883
  43. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
    Nature. 1983 Jul 7-13;304(5921):35-9 PMID: 6306471
  44. The molecular biology of platelet-derived growth factor.
    Cell. 1983 Jul;33(3):653-5 PMID: 6307524
  45. Human platelet-derived growth factor: radioimmunoassay and discovery of a specific plasma-binding protein.
    J Cell Biol. 1983 Aug;97(2):383-8 PMID: 6885904
  46. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.
    Nature. 1976 Mar 11;260(5547):170-3 PMID: 176594
  47. Induction of cell proliferation by a migration factor released from a transformed cell line.
    Exp Cell Res. 1976 Sep;101(2):293-8 PMID: 964311
  48. 125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.
    J Cell Biol. 1976 Oct;71(1):159-71 PMID: 977646
  49. An 18,000 molecular weight polypeptide induces early events and stimulates DNA synthesis in cultured cells.
    Proc Natl Acad Sci U S A. 1976 Dec;73(12):4555-9 PMID: 188046
  50. Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process.
    Proc Natl Acad Sci U S A. 1977 Oct;74(10):4481-5 PMID: 270695
  51. Glycolysis of quiescent cultures of 3T3 cells. Addition of serum, epidermal growth factor, and insulin increases the activity of phosphofructokinase in a protein synthesis-independent manner.
    J Biol Chem. 1978 Feb 10;253(3):872-7 PMID: 146038
  52. Studies of the release from human platelets of the growth factor for cultured human arterial smooth muscle cells.
    Circ Res. 1978 Mar;42(3):402-9 PMID: 624147
  53. The platelet-derived growth factor.
    Cell. 1978 Jun;14(2):203-10 PMID: 352535
  54. Chromosomes in leukemia and lymphoma.
    Semin Hematol. 1978 Jul;15(3):301-19 PMID: 353993
  55. Nerve growth factor.
    Annu Rev Biochem. 1978;47:191-216 PMID: 79332
  56. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.
    Proc Natl Acad Sci U S A. 1978 Sep;75(9):4102-6 PMID: 212733
  57. The Philadelphia chromosome in acute leukemia.
    Virchows Arch B Cell Pathol. 1978 Nov 17;29(1-2):81-91 PMID: 103315
  58. Platelet alpha-granule proteins: studies on release and subcellular localization.
    Blood. 1979 Apr;53(4):604-18 PMID: 426909
  59. Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.
    J Biol Chem. 1979 Jun 10;254(11):4884-91 PMID: 312292
  60. Dual control of cell growth by somatomedins and platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279-83 PMID: 312500
  61. Purification of human platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1979 Apr;76(4):1809-13 PMID: 287022
  62. Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle.
    Biochim Biophys Acta. 1979 Aug 10;560(2):217-41 PMID: 380651
  63. Epidermal growth factor.
    Annu Rev Biochem. 1979;48:193-216 PMID: 382984
  64. Platelet-derived growth factor: purification and partial characterization.
    Proc Natl Acad Sci U S A. 1979 Aug;76(8):3722-6 PMID: 291037
  65. Characterization by electrophoresis of epidermal growth factor stimulated phosphorylation using A-431 membranes.
    Biochemistry. 1980 Apr 1;19(7):1524-8 PMID: 6248106
  66. Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus.
    Cell. 1980 Jul;20(3):807-16 PMID: 6251974
  67. Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product.
    Cell. 1980 Oct;21(3):829-36 PMID: 6254669
  68. Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor.
    Nature. 1980 Dec 11;288(5791):600-2 PMID: 7003399
  69. Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor.
    J Cell Physiol. 1980 Nov;105(2):235-46 PMID: 6936400
  70. Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).
    Proc Natl Acad Sci U S A. 1981 Mar;78(3):1624-8 PMID: 6262821
  71. Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.
    Proc Natl Acad Sci U S A. 1981 Mar;78(3):1887-91 PMID: 6262827
  72. Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus.
    Cell. 1981 Apr;24(1):165-74 PMID: 6263485
  73. Human platelet-derived growth factor. Purification and resolution into two active protein fractions.
    J Biol Chem. 1981 Sep 10;256(17):8896-9 PMID: 7263691
  74. Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3669-72 PMID: 6943570
  75. Similarities between fibroblast-derived growth factor and platelet-derived growth factor.
    Exp Cell Res. 1981 Sep;135(1):221-7 PMID: 6456922
  76. Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor.
    Proc Natl Acad Sci U S A. 1981 Jul;78(7):4363-7 PMID: 6170063
  77. Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.
    J Biol Chem. 1981 Dec 10;256(23):12329-35 PMID: 6795201
  78. Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemia.
    Nature. 1981 Nov 19;294(5838):268-71 PMID: 6272125
  79. Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition.
    Biochem J. 1981 Mar 1;193(3):907-13 PMID: 7305965
  80. Stimulation of protein phosphorylation in Swiss mouse 3T3 cells by human platelet derived growth factor.
    Biochem Biophys Res Commun. 1981 Nov 16;103(1):355-61 PMID: 7317068
  81. Post-transcriptional control of protein synthesis in Balb/c-3T3 cells by platelet-derived growth factor and platelet-poor plasma.
    J Cell Physiol. 1981 Dec;109(3):429-38 PMID: 6798044
  82. A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.
    J Biol Chem. 1982 Feb 10;257(3):1523-31 PMID: 6276390
  83. Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.
    Nature. 1982 Jan 14;295(5845):116-9 PMID: 6173755
  84. Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor.
    Nature. 1982 Feb 4;295(5848):419-20 PMID: 6173766
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI111482
Published
1984-09-00
Pages
669-76
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC425220
Subset
IM
Grants
NCI NIH HHS · CA 22409 · United States
NHLBI NIH HHS · HL 14147 · United States
NHLBI NIH HHS · HL 22119 · United States
External Links
PubMed source DOI: 10.1172/JCI111482 PMC Full Text View journal details
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