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PMID: 6088784 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice.

Journal of virology ·Vol. 51 ·No. 3 ·1984-09-00 ·Pages 586-94

Bedigian HG, Johnson DA, Jenkins NA, Copeland NG, Evans R

Abstract

BXH-2 recombinant inbred (RI) mice produce high titers of B-ecotropic murine leukemia virus beginning early in life and have a high incidence of non-T-cell leukemias that occur before 1 year of age. The leukemias that develop are in some cases associated with hind limb paralysis. In addition, a dualtropic mink cell focus-forming virus has been isolated from leukemic cells of BXH-2 mice. Immunological and cytochemical characterization of the BXH-2 leukemias showed that they are of the myeloid lineage. To assess the oncogenicity of the BXH-2 viruses, newborn mice of several BXH RI strains were inoculated at birth with biologically cloned B-ecotropic or mink cell focus-forming murine leukemia virus. These studies demonstrated that the B-ecotropic virus can induce myeloid leukemias in other BXH RI strains, whereas the dualtropic mink cell focus-forming isolates were nononcogenic in the strains tested. DNA-DNA reassociation analysis indicated that the organotropism of the B-ecotropic murine leukemia virus is confined to lymphoid tissues. Southern analysis of tumor DNAs showed that there was amplification of ecotropic virus-specific sequences in BXH-2 myeloid tumors and in all leukemias induced in other BXH RI strains by inoculation of the BXH-2 B-ecotropic virus. Although B-ecotropic virus is expressed in central nervous tissues of paralyzed BXH-2 mice, we were unable to induce the disorder in several BXH RI strains inoculated intracranially at birth with either the B-ecotropic or dualtropic virus. These results suggest that the paralysis that occurs in BXH-2 mice is due to the infiltration of leukemic cells into the central nervous system.

MeSH Terms
Animals Antigens, Surface/analysis Cell Line DNA, Neoplasm/analysis DNA, Viral/analysis Leukemia Virus, Murine/isolation & purification Leukemia, Experimental/genetics,immunology,microbiology Mice Mice, Inbred Strains Phenotype RNA, Neoplasm/analysis RNA, Viral/analysis T-Lymphocytes/immunology
Chemicals
Antigens, Surface DNA, Neoplasm DNA, Viral RNA, Neoplasm RNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bedigian H G
Johnson D A
Jenkins N A
Copeland N G
Evans R
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.51.3.586-594.1984
Published
1984-09-00
Pages
586-94
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255802
Subset
IM
Grants
NCI NIH HHS · CA 31102 · United States
NCI NIH HHS · CA 32630 · United States
NCI NIH HHS · CA 37283 · United States
External Links
PubMed source DOI: 10.1128/JVI.51.3.586-594.1984 PMC Full Text View journal details
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