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PMID: 6091331 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Characterization of murine hepatitis virus (JHM) RNA from rats with experimental encephalomyelitis.

Virology ·Vol. 137 ·No. 2 ·1984-09-00 ·Pages 297-304

Jackson DP, Percy DH, Morris VL

Abstract

When Wistar Furth rats are inoculated intracerebrally with the murine hepatitis virus JHM they often develop a demyelinating disease with resulting hind leg paralysis. Using an RNA transfer procedure and hybridization kinetic analysis, the virus-specific RNA in these rats was characterized. The pattern of JHM-specific RNA varied with individual infections of Wistar Furth rats. However, two species of JHM-specific RNA, the nucleocapsid and a 2.1-2.4 X 10(6)-Da RNA species were generally present. A general decrease in JHM-specific RNA in brains and spinal cord samples taken later than 20 days postinoculation was observed; however, JHM-specific RNA persisted in the spinal cord longer than in the brain of these rats.

MeSH Terms

Animals Base Sequence DNA/isolation & purification Encephalomyelitis/microbiology Hepatitis, Viral, Animal/microbiology L Cells Mice Molecular Weight Murine hepatitis virus/genetics,isolation & purification RNA, Viral/genetics,isolation & purification Rats

Chemicals

RNA, Viral DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Jackson D P

Percy D H

Morris V L

References (14)

14 references, click to expand

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Article Info

Journal

Virology

Abbr.

Virology

ISSN

0042-6822

DOI

10.1016/0042-6822(84)90221-6

Published

1984-09-00

Pages

297-304

Language

English

Region

United States

NLM ID

0110674

PMCID

PMC7131065

Subset

External Links

PubMed source DOI: 10.1016/0042-6822(84)90221-6 PMC Full Text View journal details

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Characterization of murine hepatitis virus (JHM) RNA from rats with experimental encephalomyelitis.

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