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PMID: 6097674 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Multiple actions of a molluscan cardioexcitatory neuropeptide and related peptides on identified Helix neurones.

The Journal of physiology ·Vol. 356 ·1984-11-00 ·Pages 315-33

Cottrell GA, Davies NW, Green KA

Abstract

The effects of the molluscan neuropeptide Phe-Met-Arg-Phe-NH2 (FMRF amide) and related peptides (Price & Greenberg, 1977) were tested on Helix aspersa neurones. Ionophoretic application of FMRFamide depolarized and excited some neurones, but hyperpolarized and inhibited others. In some neurones the sign of the response was dependent on the membrane potential. Two responses resulted from an increase in membrane conductance, a depolarizing response mediated mainly by an increase in Na+ ion permeability, and a hyperpolarizing response mediated by an increase in K+ ion permeability. In the C1 neurone a voltage-dependent response was observed, which only occurred when the neurone was depolarized from its resting level. This response was recorded as an inward current during voltage clamp and resulted from a decrease in K current(s), possibly Ca-activated K current. More than one response may occur in a single neurone. In the C1 neurone, the K-mediated hyperpolarization occurred as well as the voltage-dependent response, while the depolarization seen in the F2 neurone was a combination of an increase in Na conductance and an increase in K conductance.

MeSH Terms
Animals Calcium/physiology Enkephalin, Methionine/analogs & derivatives,pharmacology FMRFamide Helix, Snails/physiology Ion Channels/physiology Membrane Potentials/drug effects Nerve Tissue Proteins/pharmacology Neural Conduction/drug effects Neurons/drug effects Oligopeptides/pharmacology Potassium/physiology Sodium/physiology Tetraethylammonium Tetraethylammonium Compounds/pharmacology
Chemicals
Ion Channels Nerve Tissue Proteins Oligopeptides Tetraethylammonium Compounds Enkephalin, Methionine FMRFamide Tetraethylammonium enkephalin-Met, Arg(6)-Phe(7)- phenylalanyl-norleucyl-arginyl-phenylalaninamide Sodium Potassium Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cottrell G A
Davies N W
Green K A
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43 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1984.sp015467
Published
1984-11-00
Pages
315-33
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1193166
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1984.sp015467 PMC Full Text View journal details
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