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PMID: 6107116 Published · ppublish English Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial

The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability.

British journal of clinical pharmacology ·Vol. 10 ·No. 2 ·1980-08-00 ·Pages 145-50

Hindmarch I, Gudgeon AC

Abstract

1 Laboratory tests of psychomotor performance and 'on road' assessments of car handling ability were made following repeated doses of clobazam 10 mg three times daily, lorazepam 1 mg three times daily and matching placebo 1 capsule three times daily. 2 Both active compounds produced on impairment, compared to placebo, in some mental arithmetic and letter cancellation tasks, but these effects were neither widespread nor consistent. 3 Lorazepam produced a significant impairment of car driving tasks and analogue rating scales of subjective alertness. The pronounced sedative activity of the drug was also shown in the verbal reports of side effects and in indices of early morning sedation derived from the Leeds Sleep Evaluation Questionnaire. 4 Clobazam did not produce either the objective, or the subjective impairment of performance and alertness found with lorazepam. 5 The results taken as a whole show important differences between the 1,4 benzodiazepine, lorazepam, and the 1,5 benzodiazepine, clobazam, in their effects on the integrity of psychomotor performance related to car driving ability.

MeSH Terms
Adult Analysis of Variance Anti-Anxiety Agents/adverse effects,pharmacology Attention/drug effects Automobile Driving Benzodiazepines Benzodiazepinones/pharmacology Clobazam Concept Formation/drug effects Female Humans Lorazepam/pharmacology Mental Processes/drug effects Motor Activity/drug effects Sleep/drug effects
Chemicals
Anti-Anxiety Agents Benzodiazepinones Benzodiazepines Clobazam Lorazepam
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hindmarch I
Gudgeon A C
References (29)
29 references, click to expand
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Article Info
Journal
British journal of clinical pharmacology
Abbr.
Br J Clin Pharmacol
ISSN
0306-5251
DOI
10.1111/j.1365-2125.1980.tb01731.x
Published
1980-08-00
Pages
145-50
Language
English
Region
England
NLM ID
7503323
PMCID
PMC1430040
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2125.1980.tb01731.x PMC Full Text View journal details
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