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PMID: 6125472 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

A human thy-1-like antigen expressed on cultured leukemic T-cells.

Immunogenetics ·Vol. 15 ·No. 6 ·1982-00-00 ·Pages 551-63

Saji F, Tanigaki N

Abstract

A human cell membrane antigen that is highly T-cell specific among a number of leukocyte cell lines was isolated from cells of a human T-cell leukemia cell line, SKW-3. In addition to the high specificity to T-cell-type cell lines, the isolated antigen showed the following characteristics: (1) It is an acidic glycoprotein of approximately 30 000 daltons that has a charge heterogeneity and probably a disulfide bond(s); (2) Its antigenicity is stable when treated with heat, acid, and various protein denaturants; (3) It is widely distributed in lymphoid and nonlymphoid tissues but is most predominant in brain. These features are similar, if not identical, to those reported for the Thy-1 antigen of mouse or rat and have raised the possibility that this cell membrane antigen may correspond to human "lymphocyte" Thy-1 antigen, the counterpart of human "brain" Thy-1 antigen.

MeSH Terms
Antigens, Neoplasm/isolation & purification Antigens, Surface/isolation & purification Brain/immunology Cell Line Glycoproteins/isolation & purification Humans Leukemia, Lymphoid/immunology Male Molecular Weight Organ Specificity T-Lymphocytes/immunology Testis/immunology Thy-1 Antigens
Chemicals
Antigens, Neoplasm Antigens, Surface Glycoproteins Thy-1 Antigens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Saji F
Tanigaki N
References (26)
26 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00347049
Published
1982-00-00
Pages
551-63
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI08899 · United States
NCI NIH HHS · CA16056 · United States
NCI NIH HHS · CA17276 · United States
External Links
PubMed source DOI: 10.1007/BF00347049 View journal details
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