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PMID: 6132958 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Post-tetanic decay of evoked and spontaneous transmitter release and a residual-calcium model of synaptic facilitation at crayfish neuromuscular junctions.

The Journal of general physiology ·Vol. 81 ·No. 3 ·1983-03-00 ·Pages 355-72

Zucker RS, Lara-Estrella LO

Abstract

The post-tetanic decay in miniature excitatory junction potential (MEJP) frequency and in facilitation of excitatory junction potentials (EJPs) was measured at crayfish neuromuscular junctions. A 2-s tetanus at 20 Hz caused the MEJP frequency to increase an average of 40 times and the EJP amplitude to increase an average of 13 times. Both MEJP frequency and EJP facilitation decayed with two time constants. The fast component of MEJP frequency decay was 47 ms, and that of EJP facilitation was 130 ms. The slow component of MEJP frequency decay was 0.57 s, and that of EJP facilitation was approximately 1 s. These results were consistent with the predictions of a residual calcium model, with a nonlinear relationship between presynaptic calcium concentration and transmitter release.

MeSH Terms
Animals Astacoidea Calcium/physiology Models, Biological Neuromuscular Junction/metabolism,physiology Neurotransmitter Agents/metabolism Synapses/physiology
Chemicals
Neurotransmitter Agents Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zucker R S
Lara-Estrella L O
References (37)
37 references, click to expand
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Article Info
Journal
The Journal of general physiology
Abbr.
J Gen Physiol
ISSN
0022-1295
DOI
10.1085/jgp.81.3.355
Published
1983-03-00
Pages
355-72
Language
English
Region
United States
NLM ID
2985110R
PMCID
PMC2215575
Subset
IM
Grants
NINDS NIH HHS · NS 15114 · United States
External Links
PubMed source DOI: 10.1085/jgp.81.3.355 PMC Full Text View journal details
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