Resistance to thiostrepton, siomycin, and sporangiomycin in actinomycetes that produce them.
The antibiotics thiostrepton, siomycin, and sporangiomycin are closely related both in structure and in mode of action. Actinomycetes which produce this group of compounds possess ribonucleic acid-pentose methylases, which act upon 23S ribosomal ribonucleic acid and render ribosomes resistant to the action of these antibiotics. This is achieved via the formation of a single residue of 2'-O-methyladenosine per ribosome.
5 references, click to expand
-
Antibiotic production by new form-genera of the Actinomycetales. I. Sporangiomycin, an antibacterial agent isolated from Planomonospora parontospora var. antibiotica var. nov.J Antibiot (Tokyo). 1968 Sep;21(9):525-31 PMID: 4388267
-
Studies on translocation. 3. Conditions necessary for the formation and detection of a stable ribosome-G factor-guanosine diphosphate complex in the presence of fusidic acid.J Biol Chem. 1970 Nov 10;245(21):5656-61 PMID: 4319564
-
Streptomyces laurentii, a new species producing thiostrepton.J Antibiot (Tokyo). 1977 Aug;30(8):639-43 PMID: 908663
-
Mechanism of resistance to thiostrepton in the producing-organism Streptomyces azureus.Nature. 1978 Apr 27;272(5656):792-5 PMID: 643068
-
Ribosomes in thiostrepton-resistant mutants of Bacillus megaterium lacking a single 50 S subunit protein.J Mol Biol. 1979 Aug 5;132(2):235-52 PMID: 119865
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
