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PMID: 6155421 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Dissection of the B10.D2 anti-H-2Kb cytolytic T lymphocyte receptor repertoire.

The Journal of experimental medicine ·Vol. 151 ·No. 6 ·1980-06-01 ·Pages 1386-97

Sherman LA

Abstract

The B10.D2 cytolytic T lymphocyte (CTL) receptor repertoire specific for the H-2Kb alloantigen has been studied by determining the reactivity patterns of monoclonal CTL against a panel of seven different H-2Kb mutants. The repertoire is extremely diverse and contains a minimum of approximately 50 different specificities against unique antigenic determinants on the H-2Kb molecule. Each specificity appears at a maximum frequency of 1 in 18,000 CTL precursors. These studies have also served to dissect the antigenic composition of the H-2Kb molecule. Very few CTL clonotypes share recognition of all the mutants, thereby indicating the lack of conservation of a b-type antigenic region. In addition, the degree to which each mutant shares antigenic determinants with the standard H-2Kb molecule has been determined.

MeSH Terms
Animals Clone Cells/immunology Cytotoxicity, Immunologic Epitopes H-2 Antigens/genetics Mice Mice, Inbred Strains Mutation Receptors, Immunologic/immunology T-Lymphocytes/immunology
Chemicals
Epitopes H-2 Antigens Receptors, Immunologic
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sherman L A
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.151.6.1386
Published
1980-06-01
Pages
1386-97
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185868
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.151.6.1386 PMC Full Text View journal details
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