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PMID: 6159647 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Establishment of the interferon-mediated antiviral state: role of fatty acid cyclooxygenase.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 9 ·1980-09-00 ·Pages 5437-40

Pottathil R, Chandrabose KA, Cuatrecasas P, Lang DJ

Abstract

Inhibitors of fatty acid cyclooxygenase 8,11,14-icosatrienoate, hydrogen donor:oxygen oxidoreductase, EC 1.14.99.1) were found to suppress the establishment of the interferon-mediated antiviral state. The prevention, by these compounds, of the development of interferon protection correlated with the degree as well as the duration of cyclooxygenase inhibition. Anti-inflammatory substances lacking cyclooxygenase inhibitory activity did not interfere with the establishment of interferon protection. The addition of exogenous prostaglandins was not found to replace the need for a functional cyclooxygenase and, in some instances, could be shown to diminish the establishment of interferon protection. It is proposed that fatty acid cyclooxygenase is an essential component in the optimal induction of the interferon antiviral state.

MeSH Terms
Animals Anti-Inflammatory Agents/pharmacology Cyclooxygenase Inhibitors Interferons/physiology L Cells Mice Prostaglandin-Endoperoxide Synthases/physiology Prostaglandins/biosynthesis,pharmacology Vesicular stomatitis Indiana virus/drug effects
Chemicals
Anti-Inflammatory Agents Cyclooxygenase Inhibitors Prostaglandins Interferons Prostaglandin-Endoperoxide Synthases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Pottathil R
Chandrabose K A
Cuatrecasas P
Lang D J
References (18)
18 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.9.5437
Published
1980-09-00
Pages
5437-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350074
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.9.5437 PMC Full Text View journal details
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