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PMID: 6159940 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of histamine release from human lung in vitro by antihistamines and related drugs.

British journal of pharmacology ·Vol. 69 ·No. 4 ·1980-08-00 ·Pages 663-7

Church MK, Gradidge CF

Abstract

1 A series of cationic, lipophilic histamine H1-receptor antagonists, neuroleptics, antidepressants and monoamine oxidase inhibitors were tested for their effects on anti-IgE-induced histamine release from human lung fragments in vitro. 2 They had a biphasic effect: at low concentrations a dose-related inhibition of histamine release was observed whereas, at higher concentrations, the drugs liberated histamine even in the absence of antigen. 3 Mepyramine, a much less lipophilic drug than the others tested, was only weakly active on mast cells at pharmacological concentrations. 4 The potency of the drugs as release inhibitors was not related quantitatively to their histamine liberating potency. 5 There was no; correlation between activity on mast cells and histamine H1-receptor antagonism. 6 Mast cell stabilization may play a part in the activity of these drugs as anti-allergic agents.

MeSH Terms
Chlorpheniramine/pharmacology Histamine H1 Antagonists/pharmacology Histamine Release/drug effects Humans Immunoglobulin E/immunology Lung/drug effects,metabolism Mast Cells/drug effects Pyrilamine/pharmacology
Chemicals
Histamine H1 Antagonists Immunoglobulin E Chlorpheniramine Pyrilamine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Church M K
Gradidge C F
References (26)
26 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1980.tb07919.x
Published
1980-08-00
Pages
663-7
Language
English
Region
England
NLM ID
7502536
PMCID
PMC2044314
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1980.tb07919.x PMC Full Text View journal details
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