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PMID: 91313 Published · ppublish English Journal Article

Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine.

Agents and actions ·Vol. 9 ·No. 3 ·1979-08-00 ·Pages 239-43

Johnson HG, Miller MD

Abstract

We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes.

MeSH Terms
Animals Ascitic Fluid/cytology Calcimycin/antagonists & inhibitors Calcium/metabolism Chlorpromazine/metabolism,pharmacology Histamine Release/drug effects In Vitro Techniques Lidocaine/metabolism,pharmacology Mast Cells/drug effects,metabolism Rats p-Methoxy-N-methylphenethylamine/antagonists & inhibitors
Chemicals
Calcimycin p-Methoxy-N-methylphenethylamine Lidocaine Calcium Chlorpromazine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Johnson H G
Miller M D
References (20)
20 references, click to expand
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Article Info
Journal
Agents and actions
Abbr.
Agents Actions
ISSN
0065-4299
DOI
10.1007/BF01966694
Published
1979-08-00
Pages
239-43
Language
English
Region
Switzerland
NLM ID
0213341
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01966694
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