A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice.

Immunology ·Vol. 43 ·No. 3 ·1981-07-00 ·Pages 493-501

Brickell PM, McConnell I, Milstein C, Wright B

Abstract

A rat monoclonal antibody which recognizes a product of the HLA-DR locus is described. The determinant recognized by this antibody is monomorphic in man but polymorphic in mice. Mapping studies with inbred and recombinant strains of mice show that this antigen as associated with H-2 haplotypes b, d and q and is coded for by genes within the I-A subregion.

MeSH Terms

Animals Antibodies Antibodies, Monoclonal Chromosome Mapping Clone Cells Electrophoresis, Polyacrylamide Gel Epitopes/genetics,immunology Genes, MHC Class II H-2 Antigens/genetics HLA-DR Antigens Histocompatibility Antigens Class II/immunology Humans Male Mice Molecular Weight Polymorphism, Genetic Rats

Chemicals

Antibodies Antibodies, Monoclonal Epitopes H-2 Antigens HLA-DR Antigens Histocompatibility Antigens Class II

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Brickell P M

McConnell I

Milstein C

Wright B

References (28)

28 references, click to expand

Preliminary observations on new lymphoblast strains (EB4, EB5) from Burkitt tumours in a British and a Ugandan patient.
Br J Cancer. 1966 Sep;20(3):475-9 PMID: 5922251
Morphological and virological investigations on cultured Burkitt tumor lymphoblasts (strain Raji).
J Natl Cancer Inst. 1966 Oct;37(4):547-59 PMID: 4288580
Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.
Cancer Res. 1968 Jul;28(7):1300-10 PMID: 4174339
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
Three closely linked genetic systems relevant to transplantation.
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3031-5 PMID: 4399834
Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes.
J Natl Cancer Inst. 1972 Sep;49(3):891-5 PMID: 4567231
Immunoglobulin of T lymphoma cells. Biosynthesis, surface representation, and partial characterization.
Biochemistry. 1975 May 6;14(9):1826-34 PMID: 1168492
Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.
Eur J Biochem. 1975 Aug 15;56(2):335-41 PMID: 1175627
Production of specific antisera to human B lymphocytes.
Tissue Antigens. 1976 Feb;7(2):105-17 PMID: 775683
An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection.
Intervirology. 1975;5(6):319-34 PMID: 181343
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex.
J Exp Med. 1976 Sep 1;144(3):713-25 PMID: 1085339
Studies with B-cell allo- and hetero-antisera: parallel reactivity and special properties.
Scand J Immunol. 1976;5(6-7):745-57 PMID: 62389
Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion.
Eur J Immunol. 1976 Jul;6(7):511-9 PMID: 825377
Antibodies to major histocompatibility antigens produced by hybrid cell lines.
Nature. 1977 Apr 7;266(5602):550-2 PMID: 558524
Ia antigen expression on human epidermal Langerhans cells.
Nature. 1977 Jul 21;268(5617):247-8 PMID: 329141
Expression of Ia-like antigen molecules on human granulocytes during early phases of differentiation.
Proc Natl Acad Sci U S A. 1977 Sep;74(9):4012-6 PMID: 71738
Alkaline phosphatase in Epstein-Barr viral nuclear antigen--positive cell lines.
Science. 1978 Oct 20;202(4365):318-19 PMID: 211588
Rat x rat hybrid myelomas and a monoclonal anti-Fd portion of mouse IgG.
Nature. 1979 Jan 11;277(5692):131-3 PMID: 310519
"Ia-like" antigens on human T cells.
Eur J Immunol. 1979 May;9(5):356-62 PMID: 314898
Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression.
J Exp Med. 1979 Dec 1;150(6):1472-82 PMID: 92523
B-cell alloantigens on T lymphocytes.
Transplant Proc. 1979 Dec;11(4):1774-5 PMID: 394431
Two populations of Ia-like molecules on a human B cell line.
J Immunol. 1980 Jul;125(1):293-9 PMID: 6966655
Monoclonal antibodies to Ia antigens from rat thymus: cross reactions with mouse and human and use in purification of rat Ia glycoproteins.
Immunol Rev. 1979;47:117-37 PMID: 398324
Monoclonal antibodies for analysis of the HLA system.
Immunol Rev. 1979;47:3-61 PMID: 95015
Antigenic variants of rabies virus.
J Exp Med. 1980 Jul 1;152(1):99-112 PMID: 6156982
Purification of immunologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent.
J Immunol. 1980 Oct;125(4):1421-5 PMID: 6157732
Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.
Clin Exp Immunol. 1981 Feb;43(2):291-7 PMID: 6456093
Genetics of human cell line. IV. DNA-mediated heritable transformation of a biochemical trait.
Proc Natl Acad Sci U S A. 1962 Dec 15;48:2026-34 PMID: 13980043

Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1981-07-00

Pages

493-501

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1555060

Subset

External Links

PubMed source PMC Full Text View journal details

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A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice.

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