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PMID: 6166943 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Leukocyte and fibroblast interferon genes are located on human chromosome 9.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 5 ·1981-05-00 ·Pages 3123-7

Owerbach D, Rutter WJ, Shows TB, Gray P, Goeddel DV, Lawn RM

Abstract

At least eight leukocyte interferon genes (IFL) and the single fibroblast interferon gene (IFF) have been located on chromosome 9 in humans. In somatic cell hybrids of human and mouse cells containing a normal complement of mouse parental cell chromosomes but reduced numbers of human chromosomes, the human leukocyte and fibroblast interferon DNA sequences were present only when human chromosome 9 was also present.

MeSH Terms
Animals Cell Line Chromosomes, Human/metabolism Chromosomes, Human, 6-12 and X/metabolism Clone Cells/metabolism DNA Restriction Enzymes Fibroblasts/metabolism Genes Humans Hybrid Cells/metabolism Interferons/genetics Leukocytes/metabolism Mice Nucleic Acid Hybridization
Chemicals
Interferons DNA Restriction Enzymes
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Owerbach D
Rutter W J
Shows T B
Gray P
Goeddel D V
Lawn R M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.5.3123
Published
1981-05-00
Pages
3123-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319512
Subset
IM
Grants
NIADDK NIH HHS · AM 21344 · United States
NIGMS NIH HHS · GM 20454 · United States
NICHD NIH HHS · HD 05196 · United States
External Links
PubMed source DOI: 10.1073/pnas.78.5.3123 PMC Full Text View journal details
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