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PMID: 6177216 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of ketotifen and oxatomide on histamine secretion from mast cells.

Agents and actions ·Vol. 12 ·No. 1-2 ·1982-04-00 ·Pages 206-9

Truneh A, White JR, Pearce FL

Abstract

The anti-histaminic drugs ketotifen and oxatomide have a dual effect on rat peritoneal mast cells. At high concentrations they induce histamine release, whereas at low concentrations they inhibit secretion evoked by IgE-directed ligands. The latter effect is observed in the presence and absence of exogenous calcium. The significance of this result for the general mode of action of anti-anaphylactic drugs is discussed. Neither compound liberates histamine from isolated mesenteric cells from the rat or guinea pig, further emphasizing the functional heterogeneity of mast cells from different sources.

MeSH Terms
Animals Histamine H1 Antagonists/pharmacology Histamine Release/drug effects Immunoglobulin E/physiology In Vitro Techniques Ketotifen/pharmacology Mast Cells/drug effects,metabolism Piperazines/pharmacology Rats Rats, Inbred Strains
Chemicals
Histamine H1 Antagonists Piperazines Immunoglobulin E oxatomide Ketotifen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Truneh A
White J R
Pearce F L
References (12)
12 references, click to expand
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    Br J Pharmacol Chemother. 1960 Sep;15:396-404 PMID: 13773171
  10. Oxatomide, a new orally active drug which inhibits both the release and the effects of allergic mediators.
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Article Info
Journal
Agents and actions
Abbr.
Agents Actions
ISSN
0065-4299
DOI
10.1007/BF01965147
Published
1982-04-00
Pages
206-9
Language
English
Region
Switzerland
NLM ID
0213341
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01965147
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