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PMID: 6183212 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Prediction of antigenic determinants and secondary structures of the K88 and CFA1 fimbrial proteins from enteropathogenic Escherichia coli.

Infection and immunity ·Vol. 38 ·No. 1 ·1982-10-00 ·Pages 41-5

Klemm P, Mikkelsen L

Abstract

Recently the amino acid sequences of the K88ab and the CFA1 fimbrial proteins from enteropathogenic Escherichia coli have become available. To elucidate the immunological interrelationships among the K88 family of antigenic variants, and to estimate the nature and position of the antigenic determinants in the K88 and CFA1 proteins, the positions of these features in the amino acid sequences have been predicted. This has been done by computerized algorithms, incorporating such factors as hydrophilicity and secondary structural potential. Some of the predicted determinants of K88 show good correlation with the known sequence differences between the antigenic variants of this protein. The presented results point to a possible use of synthetic vaccines against fimbriated pathogenic E. coli strains.

MeSH Terms
Amino Acid Sequence Antigens, Bacterial/immunology Antigens, Surface/immunology Computers Epitopes Escherichia coli Proteins Fimbriae Proteins Protein Conformation
Chemicals
Antigens, Bacterial Antigens, Surface Epitopes Escherichia coli Proteins K88 antigen, E coli colonization factor antigens Fimbriae Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Klemm P
Mikkelsen L
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20 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.38.1.41-45.1982
Published
1982-10-00
Pages
41-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC347694
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.38.1.41-45.1982 PMC Full Text View journal details
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