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PMID: 6188316 Published · ppublish English Journal Article

Immunohistochemical study of fibronectin in human glioma and meningioma.

Acta neuropathologica ·Vol. 59 ·No. 2 ·1983-00-00 ·Pages 119-26

Kochi N, Tani E, Morimura T, Itagaki T

Abstract

The presence of fibronectin (FN) and glial fibrillary acidic protein (GFAP) in two astrocytomas, 17 glioblastomas, and five meningiomas was studied by indirect immunoperoxidase staining of formalin-fixed and paraffin-embedded surgical specimens. Angiogenesis in tumor was scored by the microscopic angiogenesis grading system (MAGS), and plasma FN levels were measured by single radial immunodiffusion. In astrocytomas and glioblastomas, GFAP-positive tumor cells had no FN expression and FN was confined to proliferating vessel walls and the leptomeninges, showing a mutually exclusive FN and GFAP expression. GFAP-positive tumor cells were occasionally surrounded by a network of FN-positive matrix produced by cells derived from the leptomeninges or blood vessels. In meningiomas, FN expression was found in vessel walls and meningioma cells including whorl formations and psammoma bodies. In general, deep immunoperoxidase staining for FN was shown in the endothelial cells and the psammoma bodies. Plasma FN levels were correlated significantly not to the degree of leptomeningeal proliferation but to the MAGS scores in gliomas.

MeSH Terms
Astrocytoma/analysis Fibronectins/analysis,blood Glial Fibrillary Acidic Protein Glioma/analysis,blood Histocytochemistry Humans Immune Sera Immunoenzyme Techniques Intermediate Filament Proteins/analysis Meningioma/analysis,blood Neoplasms/blood supply Neovascularization, Pathologic/physiopathology
Chemicals
Fibronectins Glial Fibrillary Acidic Protein Immune Sera Intermediate Filament Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kochi N
Tani E
Morimura T
Itagaki T
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47 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00691597
Published
1983-00-00
Pages
119-26
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00691597 View journal details
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