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PMID: 6201073 Published · ppublish English Journal Article

Low-grade lymphomas. Expression of developmentally regulated B-cell antigens.

The American journal of pathology ·Vol. 115 ·No. 1 ·1984-04-00 ·Pages 117-24

Cossman J, Neckers LM, Hsu S, Longo D, Jaffe ES

Abstract

A series of low-grade B-cell lymphomas was analyzed for a battery of immunologic determinants by flow cytometry and immunohistochemistry. Histologically distinctive subclasses of these lymphomas, well-differentiated lymphocytic (WDL), intermediately differentiated lymphocytic (IDL), and follicular center cell (FCC) lymphoma, were found to be readily distinguishable by their expression of immunologic determinants that are known to be developmentally regulated in normal B cells. Although all cases expressed monoclonal surface immunoglobulin (sIg), HLA-DR, and the surface membrane proteins recognized by antibodies B1 (p32) and BA1, staining with other monoclonal antibodies revealed unique immunologic phenotypes for each subclass: WDL p65 (Leu 1)+, p24 (BA2)-; IDL p65+, p24+; FCC p65-, p24-. Additionally, the fluorescence intensities (number of determinants per cell) obtained for sIg, BA-1, and B1, but not HLA-DR, were significantly different among the three lymphoma subclasses. The relative fluorescence intensities of each of these three markers followed the same pattern: FCC greater than IDL greater than WDL. Taken together, these distinguishing features suggest that low-grade B-cell lymphomas represent arrested, and possibly sequential, stages of B-cell differentiation.

MeSH Terms
Antibodies, Monoclonal/immunology Antigens, Neoplasm/analysis Antigens, Surface/analysis B-Lymphocytes/immunology Epitopes/analysis Flow Cytometry Histocytochemistry Humans Leukemia, Lymphoid/immunology Lymphoma/immunology Lymphoma, Follicular/immunology Lymphoma, Non-Hodgkin/immunology Receptors, Antigen, B-Cell/analysis
Chemicals
Antibodies, Monoclonal Antigens, Neoplasm Antigens, Surface Epitopes Receptors, Antigen, B-Cell
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Cossman J
Neckers L M
Hsu S
Longo D
Jaffe E S
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49 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1984-04-00
Pages
117-24
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1900345
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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