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PMID: 6201867 Published · ppublish English Journal Article

Substance P modulation of acetylcholine-induced currents in embryonic chicken sympathetic and ciliary ganglion neurons.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 9 ·1984-05-00 ·Pages 2924-8

Role LW

Abstract

Substance P has been identified by combined immunohistochemical and radioimmunological techniques to be present in preganglionic cholinergic and sensory nerve fibers of amphibian, mammalian, and avian autonomic ganglia. The peptide has been shown to depolarize sympathetic neurons of frog and guinea pig and to decrease the cholinergic activation of Na+ influx and catecholamine release from chromaffin cells. The aim of this study was to examine the interaction of acetylcholine and substance P on autonomic neurons. This report demonstrates a direct effect of substance P on acetylcholine-induced inward currents in both sympathetic and parasympathetic neurons clamped near resting membrane potential. Under these conditions, substance P dramatically enhances the rate of decay of the inward current in the continued presence of agonist without substantially affecting peak inward current. This effect is consistent with an enhancement of acetylcholine-receptor desensitization. Since substance P-containing cell bodies have been demonstrated in the avian (preganglionic) column of Terni as well as in fibers from the nucleus of Edinger-Westphal, the observed peptide inhibition of cholinergic activation of the neurons may function physiologically to modulate synaptic function in autonomic ganglia.

MeSH Terms
Acetylcholine/antagonists & inhibitors,pharmacology Animals Chick Embryo Culture Techniques Drug Interactions Ganglia, Parasympathetic/drug effects Ganglia, Sympathetic/drug effects Membrane Potentials/drug effects Neural Inhibition Substance P/pharmacology Synaptic Transmission/drug effects
Chemicals
Substance P Acetylcholine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Role L W
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32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.9.2924
Published
1984-05-00
Pages
2924-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345186
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.81.9.2924 PMC Full Text View journal details
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