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PMID: 6245246 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Correlation between cell killing and massive second-round superinfection by members of some subgroups of avian leukosis virus.

Journal of virology ·Vol. 33 ·No. 1 ·1980-01-00 ·Pages 494-506

Weller SK, Joy AE, Temin HM

Abstract

Avian leukosis viruses of subgroups B, D, and F are cytopathic for chicken cells, whereas viruses of subgroups A, C, and E are not. The amounts of unintegrated linear viral DNA in cells at different times after infection with cytopathic or noncytopathic viruses were determined by hybridization and transfection assays. Shortly after infection, there is a transient accumulation of unintegrated linear viral DNA in cells infected with cytopathic avian leukosis viruses. By 10 days after infection, the majority of this unintegrated viral DNA is not present in the infected cells. The transient cytopathic effect seen in these infected cells also disappears by this time. Low amounts of unintegrated linear viral DNA persist in these cells. Cells infected with noncytopathic viruses do not show this transient accumulation of unintegrated viral DNA. Cells infected with cytopathic viruses and subsequently grown in the presence of neutralizing antibody do not show the transient accumulation of unintegrated viral DNA or cytopathic effects. These results demonstrate a correlation between envelope subgroup, transient accumulation of unintegrated linear viral DNA, and transient cell killing by avian leukosis viruses. The cell killing appears to be the result of massive second-round superinfection by the cytopathic avian leukosis viruses.

MeSH Terms
Animals Avian Leukosis Virus/analysis,genetics,growth & development Avian Sarcoma Viruses/analysis,growth & development Chick Embryo Culture Techniques Cytopathogenic Effect, Viral DNA, Viral/analysis Fibroblasts Nucleic Acid Hybridization Recombination, Genetic Virus Replication
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Weller S K
Joy A E
Temin H M
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32 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.33.1.494-506.1980
Published
1980-01-00
Pages
494-506
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC288564
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.33.1.494-506.1980 PMC Full Text View journal details
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