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PMID: 6247330 Published · ppublish English Journal Article

Changes in cyclic nucleotide levels and dimorphic transition in Candida albicans.

Journal of bacteriology ·Vol. 142 ·No. 3 ·1980-06-00 ·Pages 1010-4

Niimi M, Niimi K, Tokunaga J, Nakayama H

Abstract

The relationship between the levels of cyclic nucleotides and dimorphic transition in Candida albicans was examined. The results showed that cells of this pathogenic fungus contained both cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP), the concentration of the latter being about one-tenth that of the former in stationary-phase cells of the yeast form. Our results further indicated that germ tube formation induced by incubation at 40 degrees C followed a rise in cAMP concentration in the cell with no accompanying change in cGMP content. Cysteine, which suppressed germination, also reversed the increase in intracellular cAMP concentration. Dibutyryl cAMP (1 MM) significantly promoted germination in proline medium at temperatures of 32 to 34 degrees C. These results suggested that cAMP was one of the controlling factors in the morphological transition in Candida albicans.

MeSH Terms
Bucladesine/pharmacology Candida albicans/cytology,metabolism Cyclic AMP/metabolism Cyclic GMP/metabolism Cysteine/pharmacology Temperature
Chemicals
Bucladesine Cyclic AMP Cyclic GMP Cysteine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Niimi M
Niimi K
Tokunaga J
Nakayama H
References (25)
25 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.142.3.1010-1014.1980
Published
1980-06-00
Pages
1010-4
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC294129
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.142.3.1010-1014.1980 PMC Full Text View journal details
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