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PMID: 6253617 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A post-natal decrease in acetylcholine channel open time at rat end-plates.

The Journal of physiology ·Vol. 303 ·1980-06-00 ·Pages 125-37

Fischbach GD, Schuetze SM

Abstract

1. The mean channel open time (tau) of ACh receptors in adult developing rat skeletal muscle was estimated by analysis of ACh current fluctuations. 2. At adult end-plates, tau was 1.4 msec at 21 degrees C. Time constants of miniature end-plate current decays (taus) were equally brief. 3. On the other hand, tau and taus were long (4.5 msec, 21 degrees C) at neonatal rat end-plates. These estimates are comparable to values obtained at extrajunctional sites on embryonic rat myotubes grown in culture and on adult denervated muscle fibres. 4. Both tau and taus decreased to values characteristic of adult end-plates during the first 2 weeks after birth. 5. Complex ACh power spectra were obtained at most end-plates during the transition period and at some, miniature synaptic current decays were doubly exponential. End-plates in transition might contain a mixture of slow, neonatal channels and fast, adult channels.

MeSH Terms
Acetylcholine/metabolism Animals Animals, Newborn Culture Techniques Ion Channels/physiology Kinetics Membrane Potentials Motor Endplate/physiology Muscles/embryology,innervation Neuromuscular Junction/physiology Rats Receptors, Cholinergic/physiology
Chemicals
Ion Channels Receptors, Cholinergic Acetylcholine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fischbach G D
Schuetze S M
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34 references, click to expand
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1980.sp013275
Published
1980-06-00
Pages
125-37
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1282881
Subset
IM
Grants
NINDS NIH HHS · NS 11160 · United States
NIGMS NIH HHS · T32 GM 07226 · United States
External Links
PubMed source DOI: 10.1113/jphysiol.1980.sp013275 PMC Full Text View journal details
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