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PMID: 6253947 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

DNA sequence of the int-xis-Pi region of the bacteriophage lambda; overlap of the int and xis genes.

Nucleic acids research ·Vol. 8 ·No. 8 ·1980-04-25 ·Pages 1765-82

Davies RW

Abstract

The DNA sequence of the int and xis genes of lambda bacteriophage, as well as that of the PI promoter and a region of unknown function beyond this, was determined by the chain termination procedure. The Pribnow box sequence of the PI promoter lies just within the xis gene, and both possible sites of mRNA initiation from PI are within the xis gene. The end of the xis gene in its turn overlaps the start of the int gene by 23 base pairs, in a different reading frame. This overlap may play a role in ensuring efficient excision of the prophage in response to natural induction signals.

MeSH Terms
Amino Acid Sequence Bacteriophage lambda/analysis Base Sequence DNA Restriction Enzymes DNA, Viral Genes Genes, Viral Operon Plasmids Templates, Genetic
Chemicals
DNA, Viral DNA Restriction Enzymes
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Davies R W
References (32)
32 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/8.8.1765
Published
1980-04-25
Pages
1765-82
Language
English
Region
England
NLM ID
0411011
PMCID
PMC324034
Subset
IM
Databases
GENBANK
J02459, M17233
External Links
PubMed source DOI: 10.1093/nar/8.8.1765 PMC Full Text View journal details
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