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PMID: 6255466 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 10 ·1980-10-00 ·Pages 5799-801

Guidi-Rontani C, Danchin A, Ullmann A

Abstract

Pleiotropic carbohydrate-positive pseudorevertants have been isolated from a specific class of rho-crp double mutants of Escherichia coli carrying both defective transcription termination protein, rho, and cyclic AMP receptor protein. The modulation of catabolite repression of beta-galactosidase, amylomaltase, and tryptophanase has been studied in the pseudorevertants. It has been found that these mutants exhibit catabolite repression. Because catabolite-sensitive operons can be expressed in the absence of functional cyclic AMP receptor protein, this would suggest on the one hand that the cyclic AMP-receptor protein complex is not the exclusive mediator of catabolite repression and on the other hand that rho might be involved in the regulation of catabolite-sensitive operons.

MeSH Terms
Cyclic AMP/metabolism Enzyme Repression Escherichia coli/genetics Glucosyltransferases/genetics Glycogen Debranching Enzyme System Mutation Receptors, Cyclic AMP/genetics Rho Factor/genetics Transcription Factors/genetics Tryptophanase/genetics beta-Galactosidase/genetics
Chemicals
Glycogen Debranching Enzyme System Receptors, Cyclic AMP Rho Factor Transcription Factors Cyclic AMP Glucosyltransferases 4 alpha-glucanotransferase beta-Galactosidase Tryptophanase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Guidi-Rontani C
Danchin A
Ullmann A
References (15)
15 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.10.5799
Published
1980-10-00
Pages
5799-801
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350158
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.10.5799 PMC Full Text View journal details
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