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PMID: 6266567 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Leukotriene B4: a mediator of vascular permeability.

British journal of pharmacology ·Vol. 72 ·No. 3 ·1981-03-00 ·Pages 483-6

Bray MA, Cunningham FM, Ford-Hutchinson AW, Smith MJ

Abstract

1 Intradermal injection of leukotriene B4 (LTB4) or prostaglandin E2 (PGE2), 1 to 100 ng per skin site produced little or no change in plasma exudation in the rabbit, guinea-pig and rat. 2 Intradermal injection of LTB4 or PGE2 together with bradykinin (500 ng) resulted in a significant potentiation of the plasma exudation produced by bradykinin alone in the rabbit and guinea-pig. 4 LTB4 (1 to 10 ng) had no effect on blood flow in the rabbit skin, in contrast to PGE2 which was a potent vasodilator in this species. 5 It is concluded that LTB4 is a mediator of vascular permeability and that this effect can only be observed in the presence of a vasodilator such as PGE2.

MeSH Terms
Animals Arachidonic Acids/pharmacology Bradykinin/pharmacology Capillary Permeability/drug effects Drug Synergism Female Guinea Pigs Leukotriene B4 Prostaglandins E/pharmacology Rabbits Rats Vasodilator Agents/pharmacology
Chemicals
Arachidonic Acids Prostaglandins E Vasodilator Agents Leukotriene B4 Bradykinin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bray M A
Cunningham F M
Ford-Hutchinson A W
Smith M J
References (10)
10 references, click to expand
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  6. Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.
    J Biol Chem. 1979 Aug 25;254(16):7865-9 PMID: 468794
  7. The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs).
    J Immunol. 1980 Feb;124(2):926-33 PMID: 7356719
  8. Slow-reacting substance of anaphylaxis: studies on purification and characterisation.
    Agents Actions Suppl. 1979;(6):27-36 PMID: 43080
  9. Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B.
    Biochem Biophys Res Commun. 1980 Feb 12;92(3):954-61 PMID: 6244821
  10. Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1981.tb11000.x
Published
1981-03-00
Pages
483-6
Language
English
Region
England
NLM ID
7502536
PMCID
PMC2071580
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1981.tb11000.x PMC Full Text View journal details
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