Home LiteratureArticle Details
PMID: 6268814 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cessation of reentry of simian virus 40 DNA into replication and its simultaneous appearance in nucleoprotein complexes of the maturation pathway.

Journal of virology ·Vol. 39 ·No. 1 ·1981-07-00 ·Pages 255-62

Wang HT, Roman A

Abstract

Newly synthesized SV40 DNA is used as a template for further DNA synthesis (reenters replication) or as a substrate in the assembly of virions (maturation pathway). The time courses of reentry into replication and progression along the maturation pathway were both determined on identical samples. DNA, synthesized during a 20-min pulse, reentered replication over a period of several hours and then was removed from the pool of molecules available for replication. The cessation of reentry coincided with the maturation of this DNA from the chromatin form to previrion and virion forms. More reentry and less maturation was observed at 24 h postinfection than at 42 h postinfection. The data are consistent with the hypothesis that the factor(s) responsible for cessation of reentry is also responsible for initiation of the maturation pathway.

MeSH Terms
Animals Chlorocebus aethiops DNA Replication DNA, Viral/metabolism Deoxyribonucleoproteins/metabolism Kinetics Nucleoproteins/metabolism Simian virus 40/metabolism Virus Replication
Chemicals
DNA, Viral Deoxyribonucleoproteins Nucleoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wang H T
Roman A
References (27)
27 references, click to expand
  1. Role of fast-sedimenting SV40 nucleoprotein complexes in virus assembly.
    Virology. 1980 Apr 15;102(1):1-12 PMID: 6245498
  2. Intracellular forms of simian virus 40 nucleoprotein complexes. III. Study of histone modifications.
    J Virol. 1980 Nov;36(2):353-60 PMID: 6253661
  3. Association of simian virus 40 T antigen with replicating nucleoprotein complexes of simian virus 40.
    J Virol. 1980 Aug;35(2):320-30 PMID: 6255173
  4. Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen.
    Proc Natl Acad Sci U S A. 1980 Oct;77(10):5706-10 PMID: 6255460
  5. Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication.
    Proc Natl Acad Sci U S A. 1980 Nov;77(11):6491-5 PMID: 6256739
  6. Studies on a possible regulatory mechanism for the biosynthesis of deoxyribonucleic acid.
    J Biol Chem. 1961 Sep;236:2514-9 PMID: 13740427
  7. Induction of cellular DNA synthesis by polyoma virus.
    Proc Natl Acad Sci U S A. 1965 Jun;53(6):1468-75 PMID: 4285999
  8. Unstable DNA synthesized by polyoma virus-infected cells.
    Virology. 1966 Sep;30(1):74-81 PMID: 4287878
  9. Selective extraction of polyoma DNA from infected mouse cell cultures.
    J Mol Biol. 1967 Jun 14;26(2):365-9 PMID: 4291934
  10. Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon.
    J Virol. 1972 Oct;10(4):591-8 PMID: 4343541
  11. Resolutions and identification of the core deoxynucleoproteins of the simian virus 40.
    Biochem Biophys Res Commun. 1973 Sep 18;54(2):640-7 PMID: 4356978
  12. Regulation of tumor antigen synthesis by simain virus 40 gene A.
    J Virol. 1975 Jul;16(1):168-78 PMID: 166203
  13. Fate of polyoma form IDNA during replication.
    J Virol. 1975 Jul;16(1):70-4 PMID: 166209
  14. Autoregulation of simian virus 40 gene A by T antigen.
    Proc Natl Acad Sci U S A. 1976 Sep;73(9):3083-7 PMID: 184459
  15. The binding site on SV40 DNA for a T antigen-related protein.
    Cell. 1978 Jan;13(1):165-79 PMID: 202398
  16. Involvement of DNA polymerase alpha in simian virus 40 DNA replication.
    J Biol Chem. 1978 May 10;253(9):3273-80 PMID: 205546
  17. Recently replicated simian virus 40 DNA is a preferential template for transcription and replication.
    J Virol. 1978 May;26(2):325-34 PMID: 207891
  18. DNA polymerase alpha is associated with replicating SV40 nucleoprotein complexes.
    Nucleic Acids Res. 1978 May;5(5):1715-28 PMID: 208060
  19. The detection and characterization of multiple forms of SV40 nucleoprotein complexes.
    Virology. 1978 Oct 15;90(2):305-16 PMID: 214950
  20. Association of simian virus 40 T antigen with simian virus 40 nucleoprotein complexes.
    J Virol. 1979 Jan;29(1):232-41 PMID: 219219
  21. Intracellular forms of simian virus 40 nucleoprotein complexes. I. Methods of isolation and characterization in CV-1 cells.
    J Virol. 1979 Feb;29(2):612-23 PMID: 219250
  22. Identification and characterization of fast-sedimenting SV40 nucleoprotein complexes.
    Virology. 1979 Jul 15;96(1):54-63 PMID: 223310
  23. Kinetics of reentry of polyoma progeny form I DNA into replication as a function of time postinfection.
    Virology. 1979 Jul 30;96(2):660-3 PMID: 223323
  24. Intracellular forms of simian virus 40 nucleoprotein complexes. II. Biochemical and electron microscopic analysis of simian virus 40 virion assembly.
    J Virol. 1979 Jul;31(1):199-208 PMID: 228054
  25. Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6128-31 PMID: 230499
  26. Specific association of simian virus 40 tumor antigen with simian virus 40 chromatin.
    J Virol. 1980 Jan;33(1):78-87 PMID: 6245256
  27. Late modifications of simian virus 40 chromatin during the lytic cycle occur in an immature form of virion.
    J Virol. 1980 Mar;33(3):1138-50 PMID: 6245264
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.39.1.255-262.1981
Published
1981-07-00
Pages
255-62
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC171284
Subset
IM
Grants
NCI NIH HHS · CA-19708 · United States
NCI NIH HHS · CA-29318 · United States
External Links
PubMed source DOI: 10.1128/JVI.39.1.255-262.1981 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2