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PMID: 6269489 Published · ppublish English Journal Article

Immunological properties of beta-lactamases that hydrolyze cefuroxime and cefotaxime.

Antimicrobial agents and chemotherapy ·Vol. 20 ·No. 2 ·1981-08-00 ·Pages 262-4

Hirai K, Sato K, Matsubara N, Katsumata R, Inoue M, Mitsuhashi S

Abstract

Antiserum against purified beta-lactamase from Proteus vulgaris GN7919 cross-reacted with beta-lactamases produced by strains of Pseudomonas cepacia in a neutralization test. Anti-P. cepacia beta-lactamase serum, however, did not show any cross-reactions with P. vulgaris beta-lactamases. Each of these enzymes can hydrolyze cefuroxime and cefotaxime.

MeSH Terms
Animals Bacteria/enzymology Cefotaxime/metabolism Cefuroxime/metabolism Cephalosporinase/immunology Cephalosporins/metabolism Cross Reactions Hydrolysis Rabbits/immunology beta-Lactamases/immunology
Chemicals
Cephalosporins Cephalosporinase beta-Lactamases Cefotaxime Cefuroxime
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hirai K
Sato K
Matsubara N
Katsumata R
Inoue M
Mitsuhashi S
References (12)
12 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.20.2.262
Published
1981-08-00
Pages
262-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC181676
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.20.2.262 PMC Full Text View journal details
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