Inhibition by isoptin (a calcium antagonist) of the mitogenic stimulation of lymphocytes prior to the S-phase.

Immunology ·Vol. 34 ·No. 2 ·1978-02-00 ·Pages 303-7

Blitstein-Willinger E, Diamantstein T

Abstract

Isoptin (alpha-isopropyl-alpha-(N-methyl-N-homoveratryl)-gamma-amino-propyl-3,4-dimethoxyphenylacetonitril-hydrochloride)--a calcium antagonist--inhibits mitogenic stimulation of lymphocytes. Isoptin acts prior to the S-phase of the cehl cycle but does not prevent the early events involved in triggering of cell mitosis. The drug seems to be a good tool for studying the relevance of the 'early events' assumed to be involved in lymphocyte stimulation.

MeSH Terms

Animals Cell Cycle Female Lymphocyte Activation/drug effects Lymphocytes/immunology Mice Mice, Inbred BALB C Mitogens/pharmacology Spleen/cytology Verapamil/pharmacology

Chemicals

Mitogens Verapamil

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Blitstein-Willinger E

Diamantstein T

References (15)

15 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1978-02-00

Pages

303-7

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1457707

Subset

External Links

PubMed source PMC Full Text View journal details

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Inhibition by isoptin (a calcium antagonist) of the mitogenic stimulation of lymphocytes prior to the S-phase.

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