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PMID: 6280145 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structural analysis of repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region.

Nucleic acids research ·Vol. 10 ·No. 5 ·1982-03-11 ·Pages 1459-69

Watanabe Y, Tsukada T, Notake M, Nakanishi S, Numa S

Abstract

Repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region have been mapped and subjected to nucleotide sequence analysis. Two of the four repetitive DNA segments found are located in the 5'-flanking region, and one each within the intervening sequences. Each repetitive DNA segment contains one to three highly homologous unit sequences with an approximate length of 120 base pairs. All the unit sequences are flanked on the 3' side by tandem repeats. There are about 10(5) copies of the repetitive DNA in the bovine genome. Comparison of the bovine repetitive sequences with those of other mammalian species reveals the presence of a homologous segment of approximately 40 base pairs. This segment and the region preceding it in the bovine repetitive DNA exhibit sequence homology with the region encompassing the origin of DNA replication in papovaviruses.

MeSH Terms
Adrenocorticotropic Hormone/genetics Animals Cattle DNA/genetics DNA Restriction Enzymes Genes Plasmids Repetitive Sequences, Nucleic Acid Thymus Gland beta-Lipotropin/genetics
Chemicals
Adrenocorticotropic Hormone DNA beta-Lipotropin DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Watanabe Y
Tsukada T
Notake M
Nakanishi S
Numa S
References (28)
28 references, click to expand
  1. Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.
    Science. 1968 Aug 9;161(3841):529-40 PMID: 4874239
  2. Arrangement and characterization of repetitive sequence elements in animal DNAs.
    Cold Spring Harb Symp Quant Biol. 1974;38:295-301 PMID: 4524760
  3. Analysis of repeating DNA sequences by reassociation.
    Methods Enzymol. 1974;29:363-418 PMID: 4850571
  4. The genome of simian virus 40.
    Science. 1978 May 5;200(4341):494-502 PMID: 205947
  5. Nucleotide sequence studies of polyoma DNA. The Hpa II 3/5 junction to the Hpa II 4/Hae III 18 junction, encoding the origin of DNA replication and the 5' end of the early region.
    J Biol Chem. 1978 Sep 25;253(18):6561-7 PMID: 210189
  6. High capacity gel preparative electrophoresis for purification of fragments of genomic DNA.
    Anal Biochem. 1978 Jul 1;87(2):397-410 PMID: 686360
  7. RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):5095-9 PMID: 388428
  8. BK virus DNA: complete nucleotide sequence of a human tumor virus.
    Science. 1979 Oct 26;206(4417):456-62 PMID: 228391
  9. Selfish genes, the phenotype paradigm and genome evolution.
    Nature. 1980 Apr 17;284(5757):601-3 PMID: 6245369
  10. Selfish DNA: the ultimate parasite.
    Nature. 1980 Apr 17;284(5757):604-7 PMID: 7366731
  11. Sequencing end-labeled DNA with base-specific chemical cleavages.
    Methods Enzymol. 1980;65(1):499-560 PMID: 6246368
  12. Ubiquitous, interspersed repeated sequences in mammalian genomes.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1398-402 PMID: 6246492
  13. Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication.
    Nature. 1980 Jul 24;286(5771):352-6 PMID: 6250062
  14. Insertion of the Drosophila transposable element copia generates a 5 base pair duplication.
    Cell. 1980 Sep;21(2):575-9 PMID: 6250725
  15. Transposable elements.
    Cell. 1980 Jul;20(3):579-95 PMID: 6251969
  16. The protein-coding sequence of the bovine ACTH-beta-LPH precursor gene is split near the signal peptide region.
    Nature. 1980 Oct 23;287(5784):752-5 PMID: 6253815
  17. Analysis of the regions flanking the human insulin gene and sequence of an Alu family member.
    Nucleic Acids Res. 1980 Sep 25;8(18):4091-109 PMID: 6253909
  18. The 5' flanking region of human epsilon-globin gene.
    Nucleic Acids Res. 1980 Oct 10;8(19):4393-404 PMID: 6253916
  19. The nucleotide sequence of the ubiquitous repetitive DNA sequence B1 complementary to the most abundant class of mouse fold-back RNA.
    Nucleic Acids Res. 1980 Mar 25;8(6):1201-15 PMID: 7433120
  20. Structural analysis of interspersed repetitive polymerase III transcription units in human DNA.
    Nucleic Acids Res. 1981 Mar 11;9(5):1151-70 PMID: 7232213
  21. Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA.
    Nucleic Acids Res. 1981 Mar 11;9(5):1171-89 PMID: 7232214
  22. Isolation and characterization of the bovine corticotropin/beta-lipotropin precursor gene.
    Eur J Biochem. 1981 Apr;115(3):429-38 PMID: 6263630
  23. 5 S ribosomal RNA genes and the AluI family: evolutionary and functional significance of a region of strong homology.
    FEBS Lett. 1981 Apr 20;126(2):147-9 PMID: 7238867
  24. Structural analysis of templates and RNA polymerase III transcripts of Alu family sequences interspersed among the human beta-like globin genes.
    Gene. 1981 Mar;13(2):185-96 PMID: 6165649
  25. DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element.
    Nucleic Acids Res. 1981 May 11;9(9):2087-104 PMID: 6272224
  26. Primary structure and evolution of rat growth hormone gene.
    Proc Natl Acad Sci U S A. 1981 Aug;78(8):4867-71 PMID: 6946433
  27. Short interspersed repetitive DNA elements in eucaryotes: transposable DNA elements generated by reverse transcription of RNA pol III transcripts?
    Cell. 1981 Oct;26(2 Pt 2):141-2 PMID: 6277493
  28. The Chinese hamster Alu-equivalent sequence: a conserved highly repetitious, interspersed deoxyribonucleic acid sequence in mammals has a structure suggestive of a transposable element.
    Mol Cell Biol. 1981 Jul;1(7):573-83 PMID: 9279371
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/10.5.1459
Published
1982-03-11
Pages
1459-69
Language
English
Region
England
NLM ID
0411011
PMCID
PMC320542
Subset
IM
Databases
GENBANK
J00014, J00015, J00018, J00020
External Links
PubMed source DOI: 10.1093/nar/10.5.1459 PMC Full Text View journal details
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