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PMID: 6284647 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of lymphocytosis-promoting factor from Bordetella pertussis on cerebellar cyclic GMP levels.

Infection and immunity ·Vol. 36 ·No. 3 ·1982-06-00 ·Pages 958-61

Askelöf P, Gillenius P

Abstract

Dermonecrotic toxin (DNT), lipopolysaccharide (LPS), and lymphocytosis-promoting factor (LPF) were isolated from Bordetella pertussis and tested for neuroactivity. When injected intraperitoneally into rats, a dose of 0.13 mg of LPF per kg elevated the cyclic GMP level in cerebellum by approximately 70%, whereas DNT (0.5 mg/kg) and LPS (1.5 mg/kg) were without effect. This action of LPF on the central nervous system was dose dependent and did not require the administration of any additional agent, such as histamine.

MeSH Terms
Animals Bacterial Toxins/pharmacology Bordetella pertussis/pathogenicity Cerebellum/drug effects,metabolism Cyclic AMP/metabolism Hemagglutinins/pharmacology Interleukin-2/pharmacology Lymphokines/pharmacology Male Pertussis Toxin Rats Virulence Factors, Bordetella
Chemicals
Bacterial Toxins Hemagglutinins Interleukin-2 Lymphokines Virulence Factors, Bordetella Cyclic AMP Pertussis Toxin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Askelöf P
Gillenius P
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23 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.36.3.958-961.1982
Published
1982-06-00
Pages
958-61
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC551423
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.36.3.958-961.1982 PMC Full Text View journal details
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