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PMID: 62848 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of GIX antigen and gross cell surface antigen after infection by ecotropic and xenotropic murine leukemia viruses in vitro.

Journal of virology ·Vol. 20 ·No. 3 ·1976-12-00 ·Pages 545-54

O'Donnell PV, Stockert E

Abstract

A number of ecotropic and xenotropic murine leukemia viruses were examined for their ability to induce the GIX antigen and Gross cell surface antigen (GCSA) in tissue culture fibroblasts. GIX appears to be a constituent of murine leukemia virus gp70; a molecular characterization of GCSA has not yet been reported. Antigen induction was measured by the ability of productively infected cells to absorb cytotoxic activity from the standard GIX- and GCSA-typing antisera. Cells infected by ecotropic viruses displayed four distinct phenotypes GIX:+/GCSA++, GIX-/GCSA++, GIX++/GCSA+, and GIX-/GSCA+; cells infected by xenotropic viruses were either GIX-/GCSA+ or GIX-/GCSA-. GIX induction appeared to be a type-specific property of some but not all Gross-AKR type ecotropic viruses. Differences in the degree of absorption of the GCSA antiserum by ecotropic virus- and xenotropic virus-infected cells indicated that GCSA may comprise multiple antigenic determinants.

MeSH Terms
AKR murine leukemia virus/immunology Antigens, Viral Cell Line Cell Membrane/immunology Cytotoxicity Tests, Immunologic Epitopes Friend murine leukemia virus/immunology Leukemia Virus, Murine/immunology Moloney murine leukemia virus/immunology Rauscher Virus/immunology Species Specificity
Chemicals
Antigens, Viral Epitopes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
O'Donnell P V
Stockert E
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44 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.20.3.545-554.1976
Published
1976-12-00
Pages
545-54
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC355030
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.20.3.545-554.1976 PMC Full Text View journal details
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