Home LiteratureArticle Details
PMID: 6284999 Published · ppublish English Journal Article

Nucleotide sequence analysis of the long terminal repeat of avian myeloblastosis virus and adjacent host sequences.

Journal of virology ·Vol. 42 ·No. 3 ·1982-06-00 ·Pages 840-6

Rushlow KE, Lautenberger JA, Reddy EP, Souza LM, Baluda MA, Chirikjian JG, Papas TS

Abstract

The nucleotide sequence of the integrated avian myeloblastosis virus long terminal repeat has been determined. The sequence is 385 base pairs long and is present at both ends of the viral DNA. The cell-virus junctions at each end consist of a 6-base-pair direct repeat of cell DNA next to the inverted repeat of viral DNA. The long terminal repeat also contains promoter-like sequences, an mRNA capping site, and polyadenylation signals. Several features of this long terminal repeat suggest a structural and functional similarity with sequences of transposable and other genetic elements. Comparison of these sequences with long terminal repeats of other avian retroviruses indicates that there is a great variation in the 3' unique sequence (U3), whereas the 5' specific sequences (U5) and the R region are highly conserved.

MeSH Terms
Avian Leukosis Virus/analysis,genetics Avian Myeloblastosis Virus/analysis,genetics Avian Sarcoma Viruses/genetics Base Sequence DNA DNA, Viral/genetics Recombination, Genetic Repetitive Sequences, Nucleic Acid Transcription, Genetic
Chemicals
DNA, Viral DNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Rushlow K E
Lautenberger J A
Reddy E P
Souza L M
Baluda M A
Chirikjian J G
Papas T S
References (29)
29 references, click to expand
  1. Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter.
    Proc Natl Acad Sci U S A. 1975 Mar;72(3):784-8 PMID: 1093168
  2. A simple method for DNA restriction site mapping.
    Nucleic Acids Res. 1976 Sep;3(9):2387-98 PMID: 787937
  3. Avian myeloblastosis virus RNA is terminally redundant: implications for the mechanism of retrovirus replication.
    Cell. 1977 Sep;12(1):57-72 PMID: 198142
  4. Retroviruses.
    Annu Rev Biochem. 1978;47:35-88 PMID: 354499
  5. Avian reticuloendotheliosis viruses: evolutionary linkage with mammalian type C retroviruses.
    J Virol. 1979 May;30(2):508-14 PMID: 89204
  6. Chicken hematopoietic cells transformed by seven strains of defective avian leukemia viruses display three distinct phenotypes of differentiation.
    Cell. 1979 Oct;18(2):375-90 PMID: 227607
  7. A detailed model of reverse transcription and tests of crucial aspects.
    Cell. 1979 Sep;18(1):93-100 PMID: 509527
  8. The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.
    Cell. 1979 Nov;18(3):865-73 PMID: 519759
  9. Sequencing end-labeled DNA with base-specific chemical cleavages.
    Methods Enzymol. 1980;65(1):499-560 PMID: 6246368
  10. Computer analysis of nucleic acids and proteins.
    Methods Enzymol. 1980;65(1):595-609 PMID: 6154871
  11. Identification of a proviral genome associated with avian myeloblastic leukemia.
    Proc Natl Acad Sci U S A. 1980 May;77(5):3004-8 PMID: 6248880
  12. Sequence of retrovirus provirus resembles that of bacterial transposable elements.
    Nature. 1980 Jun 19;285(5766):550-4 PMID: 6250038
  13. Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication.
    Nature. 1980 Jul 24;286(5771):352-6 PMID: 6250062
  14. Insertion of the Drosophila transposable element copia generates a 5 base pair duplication.
    Cell. 1980 Sep;21(2):575-9 PMID: 6250725
  15. Terminal repeats of the Drosophila transposable element copia: nucleotide sequence and genomic organization.
    Cell. 1980 Sep;21(2):581-8 PMID: 6250726
  16. The origins of gene instability in yeast.
    Science. 1980 Sep 19;209(4463):1375-80 PMID: 6251544
  17. Identification of the avian myeloblastosis virus genome. I. Identification of restriction endonuclease fragments associated with acute myeloblastic leukemia.
    J Virol. 1980 Nov;36(2):317-24 PMID: 6253658
  18. Identification of the avian myeloblastosis virus genome. II. Restriction endonuclease analysis of DNA from lambda proviral recombinants and leukemic myeoblast clones.
    J Virol. 1980 Nov;36(2):325-36 PMID: 6253659
  19. Nucleotide sequences of integrated Moloney sarcoma provirus long terminal repeats and their host and viral junctions.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):3937-41 PMID: 6254003
  20. Genetic structure of avian myeloblastosis virus, released from transformed myeloblasts as a defective virus particle.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5120-4 PMID: 6159639
  21. Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5234-8 PMID: 6254069
  22. The structure and evolution of the human beta-globin gene family.
    Cell. 1980 Oct;21(3):653-68 PMID: 6985477
  23. Nucleotide sequence analysis of the long terminal repeat (LTR) of avian retroviruses: structural similarities with transposable elements.
    Cell. 1980 Nov;22(2 Pt 2):379-86 PMID: 6256079
  24. Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.
    Cell. 1980 Dec;22(3):787-97 PMID: 6257399
  25. Nucleotide sequence of acceptor site and termini of integrated avian endogenous provirus ev1: integration creates a 6 bp repeat of host DNA.
    Cell. 1981 Jan;23(1):155-64 PMID: 6260371
  26. Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements.
    Proc Natl Acad Sci U S A. 1981 Jan;78(1):124-8 PMID: 6264426
  27. Analysis of avian myeloblastosis viral RNA and in vitro synthesis of proviral DNA.
    Proc Natl Acad Sci U S A. 1981 Apr;78(4):2057-61 PMID: 6264460
  28. A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration.
    Proc Natl Acad Sci U S A. 1981 Jul;78(7):4299-303 PMID: 6270669
  29. Enhanced graphic matrix analysis of nucleic acid and protein sequences.
    Proc Natl Acad Sci U S A. 1981 Dec;78(12):7665-9 PMID: 6801656
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.42.3.840-846.1982
Published
1982-06-00
Pages
840-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256917
Subset
IM
Databases
GENBANK
K00387, K00388
External Links
PubMed source DOI: 10.1128/JVI.42.3.840-846.1982 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2