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PMID: 6286125 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Characterization of the dopamine stimulated adenylate cyclase in the pedal ganglia of Mytilus edulis: interactions with etorphine, beta-endorphin, DALA, and methionine enkephalin.

Cellular and molecular neurobiology ·Vol. 1 ·No. 1 ·1981-03-00 ·Pages 57-68

Stefano GB, Catapane EJ, Kream RM

Abstract

The dopamine-stimulated adenylate cyclase activity was studied both in vivo and in vitro in the central nervous system of the bivalve mollusc Mytilus edulis. Dopamine, epinine, and apomorphine stimulated the enzyme system. Fluphenazine, haloperidol, chlorpromaxine, and to a lesser extent BOL inhibited the dopamine-stimulated adenylate cyclase. Etorphine, beta-endorphine, DALA, and methionine enkephalin depressed cyclic AMP levels. This phenomena was naloxone reversible. In addition, the opioids inhibited the stimulation of adenylate cyclase by dopamine. This phenomena was also naloxone reversible. The study demonstrates an interaction among dopamine, the opioids, and cyclic AMP.

MeSH Terms
Adenylyl Cyclases/metabolism Animals Bivalvia Dopamine/pharmacology Endorphins/pharmacology Enkephalin, Methionine Enkephalins/pharmacology Etorphine/pharmacology Ganglia/enzymology Kinetics Morphinans/pharmacology beta-Endorphin
Chemicals
Endorphins Enkephalins Morphinans Etorphine Enkephalin, Methionine beta-Endorphin enkephalinamide-Met, Ala(2)- Adenylyl Cyclases Dopamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stefano G B
Catapane E J
Kream R M
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28 references, click to expand
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Article Info
Journal
Cellular and molecular neurobiology
Abbr.
Cell Mol Neurobiol
ISSN
0272-4340
DOI
10.1007/BF00736039
Published
1981-03-00
Pages
57-68
Language
English
Region
United States
NLM ID
8200709
Subset
IM
Grants
NIGMS NIH HHS · 1-T32GM07641-01 · United States
NCRR NIH HHS · 1S06RR08171-01 · United States
External Links
PubMed source DOI: 10.1007/BF00736039 View journal details
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