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PMID: 6286842 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Block of outward current in cardiac Purkinje fibers by injection of quaternary ammonium ions.

The Journal of general physiology ·Vol. 79 ·No. 6 ·1982-06-00 ·Pages 1041-63

Kass RS, Scheuer T, Malloy KJ

Abstract

We have studied the effects of iontophoretic injection of the quaternary ammonium compounds tetraethylammonium (TEA) and tetrabutylammonium (TBA) in cardiac purkinje fibers. We find that TBA(+) is a more effective blocker than TEA(+), but injection of either compound reduces the time-dependent outward plateau currents, transient outward current (I(to)), and the delayed rectifier (I(x)). Our findings provide evidence that these outward cardiac currents are carried by channels that in some respects are pharmacologically similar to squid axon potassium channels. We demonstrate that this procedure is a new tool that can be useful in the analysis of membrane currents in the heart.

MeSH Terms
Animals Cattle Electric Conductivity/drug effects Heart Conduction System/drug effects Ion Channels/drug effects Iontophoresis Muscle Contraction/drug effects Purkinje Fibers/drug effects Quaternary Ammonium Compounds/administration & dosage,pharmacology Tetraethylammonium Tetraethylammonium Compounds/administration & dosage,pharmacology Time Factors
Chemicals
Ion Channels Quaternary Ammonium Compounds Tetraethylammonium Compounds Tetraethylammonium tetrabutylammonium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kass R S
Scheuer T
Malloy K J
References (31)
31 references, click to expand
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Article Info
Journal
The Journal of general physiology
Abbr.
J Gen Physiol
ISSN
0022-1295
DOI
10.1085/jgp.79.6.1041
Published
1982-06-00
Pages
1041-63
Language
English
Region
United States
NLM ID
2985110R
PMCID
PMC2216454
Subset
IM
Grants
NHLBI NIH HHS · HL 21922 · United States
NHLBI NIH HHS · HL00556 · United States
External Links
PubMed source DOI: 10.1085/jgp.79.6.1041 PMC Full Text View journal details
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