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PMID: 6292259 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

The biology of the human natural killer cell.

Journal of clinical immunology ·Vol. 2 ·No. 4 ·1982-10-00 ·Pages 249-63

Roder JC, Pross HF

Abstract

Natural killer (NK) cells in the human are a population of large granular lymphocytes (LGL) with at least one unique surface antigen not expressed on cells of other lineages. NK-target-cell interaction appears to involve carbohydrate recognition and, following binding, the NK cells are induced to generate O2-, transmethylate membrane phospholipids, and activate phospholipase A2. Some or all of these activities trigger a cascade of events which ultimately leads to the secretion of a substance toxic to the target cell. A variety of genes controls various steps in this cytolytic pathway. There is a good deal of evidence in the mouse, and some in the human, that NK cells play a role in host surveillance against tumor development, resistance to viral infections, and, possibly, hematopoietic regulation.

MeSH Terms
Animals Cytoplasmic Granules/metabolism Cytotoxicity, Immunologic Female Hematopoiesis Humans Immune System Diseases/immunology Killer Cells, Natural/immunology,physiology Male Membrane Lipids/metabolism Mice Models, Biological Neoplasms/immunology Receptors, Immunologic Superoxides/metabolism
Chemicals
Membrane Lipids Receptors, Immunologic Superoxides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Roder J C
Pross H F
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00915064
Published
1982-10-00
Pages
249-63
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00915064 View journal details
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