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PMID: 6292910 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Human type I procollagen genes are located on different chromosomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 21 ·1982-11-00 ·Pages 6627-30

Huerre C, Junien C, Weil D, Chu ML, Morabito M, Van Cong N, Myers JC, Foubert C, Gross MS, Prockop DJ, Boué A, Kaplan JC, de la Chapelle A, Ramirez F

Abstract

A recombinant plasmid containing sequences complementary to human pro-alpha l(I) collagen mRNA was used for the chromosomal assignment of the pro-alpha l(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosomes with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-alpha l(I) gene with the segment 17q21 leads to qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

MeSH Terms
Amino Acid Sequence Chromosome Mapping Chromosomes, Human, 16-18 Chromosomes, Human, 6-12 and X DNA Restriction Enzymes Genes Humans Procollagen/genetics
Chemicals
Procollagen DNA Restriction Enzymes
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Huerre C
Junien C
Weil D
Chu M L
Morabito M
Van Cong N
Myers J C
Foubert C
Gross M S
Prockop D J
Boué A
Kaplan J C
de la Chapelle A
Ramirez F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.21.6627
Published
1982-11-00
Pages
6627-30
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347181
Subset
IM
Grants
NIADDK NIH HHS · AM-16516 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.21.6627 PMC Full Text View journal details
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