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PMID: 630042 Published · ppublish English Journal Article

The effects of calcium++ on bursting neurons. A modeling study.

Biophysical journal ·Vol. 21 ·No. 3 ·1978-03-00 ·Pages 217-37

Plant RE

Abstract

Many observed effects of ionized calcium on bursting pacemaker neurons may be accounted for by assuming that calcium has multiple effects on the membrane conductance mechanisms. Two models are proposed that represent extreme cases of a set of possible models for these multiple effects. Both models are a priori designed to account for directly observed phenomena, and both are found to be able to simulate a posteriori certain observed phenomena, including persistent inactivation, increasing spike width, and decreasing after-polarization. Experimental tests are proposed for the decision of validity between the set of models discussed and the null hypothesis, and for the decision of validity between the two models themselves. Extensions of the models are discussed. One of these extensions leads to a simulation of the behavior of the cell when placed in a calcium-free bathing medium.

MeSH Terms
Animals Calcium/pharmacology Cell Membrane/drug effects,physiology Electric Conductivity Mathematics Models, Biological Neurons/drug effects,physiology
Chemicals
Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Plant R E
References (46)
46 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(78)85521-0
Published
1978-03-00
Pages
217-37
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1473693
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(78)85521-0 PMC Full Text View journal details
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