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PMID: 6300423 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins.

Journal of virology ·Vol. 45 ·No. 2 ·1983-02-00 ·Pages 600-6

Prieto-Soto A, Gourlie B, Miwa M, Pigiet V, Sugimura T, Malik N, Smulson M

Abstract

The host nuclear enzyme poly(ADP-ribose) polymerase has been shown to be associated with the replicative intermediate and mature forms of polyoma virus minichromosomes. Minichromosome-associated histones H2A and H2B as well as several nonhistone proteins were poly ADP-ribosylated by endogenous poly(ADP-ribose) polymerase. In addition, minichromosome fractions catalyzed the formation in vitro of dimers of endogenous histone H1 linked by poly(ADP-ribose). Poly ADP-ribosylated polyoma virus minichromosome chromatin labeled in vivo with [3H]thymidine could be retained and eluted from anti-poly(ADP-ribose) immunoglobulin G-Sepharose. Pulse-labeled replicative intermediate minichromosomes were retained better on the antibody columns than were mature minichromosomes labeled for 2.5 h. The possible role of poly ADP-ribosylation of viral nucleosomes during polyoma replication or transcription is discussed.

MeSH Terms
Chromatin/metabolism Chromatography, Affinity Chromosomal Proteins, Non-Histone/metabolism Histones/metabolism NAD+ Nucleosidase/metabolism Nucleoside Diphosphate Sugars/metabolism Poly Adenosine Diphosphate Ribose/metabolism Poly(ADP-ribose) Polymerases/metabolism Polyomavirus/genetics Virus Replication
Chemicals
Chromatin Chromosomal Proteins, Non-Histone Histones Nucleoside Diphosphate Sugars Poly Adenosine Diphosphate Ribose Poly(ADP-ribose) Polymerases NAD+ Nucleosidase
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Prieto-Soto A
Gourlie B
Miwa M
Pigiet V
Sugimura T
Malik N
Smulson M
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30 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.45.2.600-606.1983
Published
1983-02-00
Pages
600-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC256454
Subset
IM
Grants
NCI NIH HHS · CA 13195 · United States
NCI NIH HHS · CA 25344 · United States
NIGMS NIH HHS · GM 23813 · United States
External Links
PubMed source DOI: 10.1128/JVI.45.2.600-606.1983 PMC Full Text View journal details
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