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PMID: 6300911 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 8 ·1983-04-00 ·Pages 2346-50

Fujinami RS, Oldstone MB, Wroblewska Z, Frankel ME, Koprowski H

Abstract

Using monoclonal antibodies, we demonstrate that the phosphoprotein of measles virus and a protein of herpes simplex virus type 1 crossreact with an intermediate filament protein of human cells. This intermediate filament protein, probably vimentin, has a molecular weight of 52,000, whereas the molecular weights of the measles viral phosphoprotein and the herpes virus protein are 70,000 and 146,000, respectively. Crossreactivity was shown by immunofluorescent staining of infected and uninfected cells and by immunoblotting. The monoclonal antibody against measles virus phosphoprotein did not react with herpes simplex virus protein and vice versa, indicating that these monoclonal antibodies recognize different antigenic determinants on the intermediate filament molecule. The significance of these results in explaining the appearance of autoantibodies during virus infections in humans is discussed.

MeSH Terms
Antibodies, Monoclonal Cross Reactions Intermediate Filament Proteins/immunology Measles virus/immunology Molecular Weight Phosphoproteins/immunology Simplexvirus/immunology Vimentin Viral Proteins/immunology
Chemicals
Antibodies, Monoclonal Intermediate Filament Proteins Phosphoproteins Vimentin Viral Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Fujinami R S
Oldstone M B
Wroblewska Z
Frankel M E
Koprowski H
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32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.8.2346
Published
1983-04-00
Pages
2346-50
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC393817
Subset
IM
Grants
NIAID NIH HHS · AI-16102 · United States
NINDS NIH HHS · NS-12428 · United States
NINDS NIH HHS · NS-17214 · United States
External Links
PubMed source DOI: 10.1073/pnas.80.8.2346 PMC Full Text View journal details
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