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PMID: 6310072 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

An outbreak of rotavirus-associated neonatal necrotizing enterocolitis.

The Journal of pediatrics ·Vol. 103 ·No. 3 ·1983-09-00 ·Pages 454-9

Rotbart HA, Levin MJ, Yolken RH, Manchester DK, Jantzen J

Abstract

An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P = 0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.

MeSH Terms
Cross Infection/epidemiology,microbiology Disease Outbreaks/epidemiology Enterocolitis, Pseudomembranous/epidemiology,microbiology Feces/microbiology Gastroenteritis/epidemiology,microbiology Gastrointestinal Hemorrhage/epidemiology,microbiology Humans Infant, Newborn Infant, Newborn, Diseases/epidemiology,microbiology Nurseries, Hospital Reoviridae Infections/epidemiology Rotavirus/isolation & purification
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rotbart H A
Levin M J
Yolken R H
Manchester D K
Jantzen J
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31 references, click to expand
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Article Info
Journal
The Journal of pediatrics
Abbr.
J Pediatr
ISSN
0022-3476
DOI
10.1016/s0022-3476(83)80427-2
Published
1983-09-00
Pages
454-9
Language
English
Region
United States
NLM ID
0375410
PMCID
PMC7131059
Subset
IM
Grants
DRS NIH HHS · BRSG-05357 · United States
NIAID NIH HHS · N01-AI-23660 · United States
NIAID NIH HHS · R01-AI-17604 · United States
External Links
PubMed source DOI: 10.1016/s0022-3476(83)80427-2 PMC Full Text View journal details
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