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PMID: 6310555 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 19 ·1982-10-00 ·Pages 5916-20

Heller M, Henderson A, Kieff E

Abstract

The third internal repeat (IR3) simple repeat array in Epstein-Barr virus (EBV) DNA has a high degree of homology to a reiterated component of cell DNAs. 32P-Labeled human or mouse DNAs hybridize to the IR3 sequence on Southern blots of viral DNA. EBV IR3 probe identifies many restriction enzyme fragments on Southern blots of human and mouse DNAs that have extensive homology to IR3. Cytological hybridization shows that IR3 is homologous to at least one region on each human chromosome except the Y chromosome.

MeSH Terms
Animals Burkitt Lymphoma Cell Line Cell Transformation, Viral Chromosomes, Human/analysis DNA/genetics DNA Restriction Enzymes DNA, Recombinant/analysis DNA, Viral/genetics Herpesvirus 4, Human/genetics Humans L Cells/analysis Mice Nucleic Acid Hybridization Plasmids Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
DNA, Recombinant DNA, Viral DNA DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Heller M
Henderson A
Kieff E
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.19.5916
Published
1982-10-00
Pages
5916-20
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347021
Subset
IM
Grants
NCI NIH HHS · CA 17281 · United States
NCI NIH HHS · CA 19264 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.19.5916 PMC Full Text View journal details
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