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PMID: 6312449 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 20 ·1983-10-00 ·Pages 6229-33

Stephens RM, Rice NR, Hiebsch RR, Bose HR, Gilden RV

Abstract

The nucleotide sequence of v-rel, the oncogene carried by reticuloendotheliosis virus (REV), has been determined. The defective transforming genome REV arose through the insertion of v-rel (1,415 nucleotides) into the env gene of the helper virus REV-A. The predicted rel protein (503 amino acids) employs the REV-A env initiator and terminates within the p20E region of env. Because there are no natural antisera that detect the REV transforming protein, this nucleotide sequence provides the first step toward its isolation and characterization. The predicted protein is clearly distinct from all other reported transforming proteins but may be very distantly related to members of the src family.

MeSH Terms
Amino Acid Sequence Base Sequence Cell Transformation, Viral Genes, Viral Oncogenes Reticuloendotheliosis virus/genetics Retroviridae/genetics Viral Envelope Proteins/genetics Viral Proteins/genetics
Chemicals
Viral Envelope Proteins Viral Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Stephens R M
Rice N R
Hiebsch R R
Bose H R
Gilden R V
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.20.6229
Published
1983-10-00
Pages
6229-33
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC394269
Subset
IM
Grants
NCI NIH HHS · CA26169 · United States
NCI NIH HHS · N01-CO-23909 · United States
Databases
GENBANK
K00555, K02537
External Links
PubMed source DOI: 10.1073/pnas.80.20.6229 PMC Full Text View journal details
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