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PMID: 6315580 Published · ppublish English Journal Article

Mechanisms of enhanced resistance of Mycobacterium bovis BCG-treated mice to ectromelia virus infection.

Infection and immunity ·Vol. 42 ·No. 2 ·1983-11-00 ·Pages 567-73

Sakuma T, Suenaga T, Yoshida I, Azuma M

Abstract

The mechanism of enhanced resistance of Mycobacterium bovis BCG-treated mice to ectromelia virus infection was investigated by determining the effect of splenectomy, antithymocyte serum, and antimacrophage serum on resistance. It was greatly reduced by these treatments, not only in normal mice, but also in mice treated with live or heat-inactivated BCG. Production of circulating interferon by ectromelia virus and Newcastle disease virus was augmented in BCG-treated mice and was markedly depressed by splenectomy and antithymocyte and antimacrophage serum treatments in both BCG-treated and normal mice. Carbon clearance activity was activated in BCG-treated mice, but splenectomy did not influence phagocytic activity. These results suggest that augmented interferon production in the spleens of BCG-treated mice plays a major role in enhanced resistance. Other possible mechanisms are discussed.

MeSH Terms
Animals Ectromelia virus/immunology Ectromelia, Infectious/immunology,microbiology Female Immunity, Innate Interferon Type I/genetics Kinetics L Cells/immunology Mice Mice, Inbred Strains Mycobacterium bovis/immunology Newcastle disease virus/immunology Poxviridae Infections/microbiology Splenectomy Time Factors
Chemicals
Interferon Type I
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sakuma T
Suenaga T
Yoshida I
Azuma M
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37 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.42.2.567-573.1983
Published
1983-11-00
Pages
567-73
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264465
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.42.2.567-573.1983 PMC Full Text View journal details
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