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PMID: 6321162 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

DNA sequence and genome organization of genital human papillomavirus type 6b.

The EMBO journal ·Vol. 2 ·No. 12 ·1983-00-00 ·Pages 2341-8

Schwarz E, Dürst M, Demankowski C, Lattermann O, Zech R, Wolfsperger E, Suhai S, zur Hausen H

Abstract

The complete nucleotide sequence of the circular double-stranded DNA of the genital human papillomavirus type 6b (HPV6b) comprising 7902 bp was determined and compared with the DNA sequences of human papillomavirus type 1a (HPV1a) and bovine papillomavirus type 1 (BPV1). All major open reading frames are located on one DNA strand only. Their arrangement reveals that the genomic organization of HPV6b is similar to that of HPV1a and BPV1. The putative early region includes two large open reading frames E1 and E2 with marked amino acid sequence homologies to HPV1a and BPV1 which are flanked by several smaller frames. The internal part of E2 completely overlaps with another open reading frame E4. The putative late region contains two large open reading frames L1 and L2. The L1 amino acid sequences are highly conserved among analyzed papillomavirus types. By sequence comparison, potential promoter, splicing and polyadenylation signals can be localized in HPV6b DNA suggesting possible mechanisms of genital papillomavirus gene expression.

MeSH Terms
Amino Acid Sequence Base Sequence Computers DNA, Viral/genetics Genes, Viral Humans Papillomaviridae/genetics Plasmids Transcription, Genetic
Chemicals
DNA, Viral
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Schwarz E
Dürst M
Demankowski C
Lattermann O
Zech R
Wolfsperger E
Suhai S
zur Hausen H
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1983-00-00
Pages
2341-8
Language
English
Region
England
NLM ID
8208664
PMCID
PMC555455
Subset
IM
Databases
GENBANK
X00203
External Links
PubMed source PMC Full Text View journal details
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