Analysis of carbamazepine actions in hippocampal slices of the rat.

Cellular and molecular neurobiology ·Vol. 3 ·No. 3 ·1983-09-00 ·Pages 213-22

Hood TW, Siegfried J, Haas HL

Abstract

Carbamazepine at therapeutic concentrations has a strong inhibitory effect on the spontaneous field bursts of the CA 1 region of rat hippocampal slices in low-Ca2+, high-Mg2+ solution. A reduction of excitability and synaptic transmission as well as no effect on posttetanic potentiation in the rat hippocampal slice by carbamazepine agrees with previous studies on spinal cord and peripheral nerve. Carbamazepine left synaptic inhibition and hyperpolarizing afterpotentials unaltered while these inhibitory processes were markedly enhanced by pentobarbital and adenosine, respectively. The spontaneous field bursts are, at least in part, synchronized by ephaptic transmission and may serve as a model of epilepsy and trigeminal neuralgia. The clinical effectiveness of carbamazepine in these two ailments may be explained by a suppression of this pathological synchronization.

MeSH Terms

Adenosine/pharmacology Afferent Pathways/drug effects Animals Carbamazepine/pharmacology Culture Techniques Dose-Response Relationship, Drug Evoked Potentials/drug effects Hippocampus/drug effects Ion Channels/drug effects Neural Inhibition/drug effects Pentobarbital/pharmacology Rats Synapses/drug effects Synaptic Transmission/drug effects

Chemicals

Ion Channels Carbamazepine Pentobarbital Adenosine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hood T W

Siegfried J

Haas H L

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20 references, click to expand

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Article Info

Journal

Cellular and molecular neurobiology

Abbr.

Cell Mol Neurobiol

ISSN

0272-4340

DOI

10.1007/BF00710948

Published

1983-09-00

Pages

213-22

Language

English

Region

United States

NLM ID

8200709

Subset

External Links

PubMed source DOI: 10.1007/BF00710948 View journal details

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Analysis of carbamazepine actions in hippocampal slices of the rat.

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