Home LiteratureArticle Details
PMID: 6324067 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Modulation of low calcium induced field bursts in the hippocampus by monoamines and cholinomimetics.

Pflugers Archiv : European journal of physiology ·Vol. 400 ·No. 1 ·1984-01-00 ·Pages 28-33

Haas HL, Jefferys JG, Slater NT, Carpenter DO

Abstract

The influence of monoamine transmitter candidates, acetylcholine and related substances on rhythmic depolarization shifts (field bursts) in the CA 1 area of hippocampal slices from rats in low calcium (0.2 mmol X 1(-1) ) high magnesium (4 mmol X 1(-1) ) was investigated. Acetylcholine (ACh), histamine (HA) and H2-agonists, noradrenaline (NA) and beta-agonists at nano- to micromolar concentrations as well as dopamine (DA) and 8-bromo-cyclic AMP at 100 mumol X 1(-1) accelerated the field bursts. H2-antagonists blocked HA actions, beta-antagonists blocked NA actions selectively; muscarinic antagonists blocked ACh, HA and NA actions. H1-agonists, serotonin, dopamine and adenosine slowed the field bursts at micromolar concentrations. These effects parallel the action of the tested substances on afterhyperpolarizations in CA 1 pyramidal cells. High sensitivity and specificity make this response of the field bursts an excellent model to study postsynaptic transmitter actions in the central nervous system.

MeSH Terms
Animals Calcium/pharmacology Catecholamines/pharmacology Cyclic AMP/pharmacology Electrophysiology Hippocampus/drug effects,physiology Histamine/pharmacology Parasympathomimetics/pharmacology Rats Serotonin/pharmacology
Chemicals
Catecholamines Parasympathomimetics Serotonin Histamine Cyclic AMP Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Haas H L
Jefferys J G
Slater N T
Carpenter D O
References (40)
40 references, click to expand
  1. Spontaneous epileptiform activity of CA1 hippocampal neurons in low extracellular calcium solutions.
    Exp Brain Res. 1983;51(1):153-6 PMID: 6884463
  2. Mechanisms of norepinephrine actions on hippocampal pyramidal cells in vitro.
    Brain Res. 1981 Mar 16;208(2):349-62 PMID: 6260288
  3. Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus.
    Nature. 1982 Oct 14;299(5884):636-8 PMID: 6289127
  4. Noradrenergic responses in rat hippocampus: evidence for medication by alpha and beta receptors in the in vitro slice.
    Brain Res. 1981 Jun 9;214(1):113-26 PMID: 6263414
  5. Intracellular observations on the disinhibitory action of acetylcholine in the hippocampus.
    Neuroscience. 1981;6(12):2475-84 PMID: 7322346
  6. Definition and antagonism of histamine H 2 -receptors.
    Nature. 1972 Apr 21;236(5347):385-90 PMID: 4401751
  7. Localization of transmitter candidates in the brain: the hippocampal formation as a model.
    Prog Neurobiol. 1977;8(2):119-81 PMID: 14356
  8. Histamine and metabolites: their effects and interactions with convulsants on brain stem neurones.
    Brain Res. 1973 Mar 15;51:269-78 PMID: 4145193
  9. Histamine modulates reactivity of hippocampal CA3 neurons to afferent stimulation in vitro.
    Brain Res. 1981 Jun 1;213(2):443-8 PMID: 7248769
  10. Hippocampal noradrenergic responses in vivo and in vitro. Characterization of alpha and beta components.
    Naunyn Schmiedebergs Arch Pharmacol. 1982 Mar;318(4):259-66 PMID: 6281666
  11. Inhibition of cortical neurones by imidazole and some derivatives.
    Can J Physiol Pharmacol. 1973 Nov;51(11):790-7 PMID: 4762426
  12. Elucidation of the mechanism and site of action of quinuclidinyl benzilate (QNB) on the electrical excitability and chemosensitivity of the frog sartorius muscle.
    Cell Mol Neurobiol. 1981 Jun;1(2):209-30 PMID: 6980708
  13. Histamine hyperpolarizes hippocampal neurones in vitro.
    Neurosci Lett. 1981 Feb 23;22(1):75-8 PMID: 6452591
  14. The membrane potential of cat hippocampal neurons recorded in vivo displays four different reaction-mechanisms to iontophoretically applied transmitter agonists.
    Brain Res. 1981 May 18;212(2):331-43 PMID: 6112049
  15. Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells.
    Nature. 1983 Mar 31-Apr 6;302(5907):432-4 PMID: 6300681
  16. Hypersensitivity to histamine in the guinea-pig brain: microiontophoretic and biochemical studies.
    Brain Res. 1978 Nov 10;156(2):275-91 PMID: 213164
  17. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons.
    Brain Res. 1982 Oct 28;250(1):71-92 PMID: 6128061
  18. Cholinergic disinhibition in hippocampal slices of the rat.
    Brain Res. 1982 Feb 4;233(1):200-4 PMID: 7059802
  19. Histamine H2-receptors on single central neurones.
    Nature. 1975 Jun 19;255(5510):634-5 PMID: 237236
  20. A simple perfusion chamber for the study of nervous tissue slices in vitro.
    J Neurosci Methods. 1979 Dec;1(4):323-5 PMID: 544974
  21. Kinetic analysis of end plate currents altered by atropine and scopolamine.
    Mol Pharmacol. 1978 May;14(3):514-29 PMID: 307112
  22. The action of serotonin in the rat hippocampal slice preparation.
    J Physiol. 1980 Jun;303:423-39 PMID: 6253621
  23. H1 and H2 histamine receptors on Aplysia neurones.
    Nature. 1975 Mar 27;254(5498):343-4 PMID: 163982
  24. Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses.
    Science. 1982 Nov 19;218(4574):810-2 PMID: 7134978
  25. Dopamine receptor binding: specificity, localization and regulation by ions and guanyl nucleotides.
    Life Sci. 1978 Aug 7;23(5):495-9 PMID: 692273
  26. The excitatory action of acetylcholine on hippocampal neurones of the guinea pig and rat maintained in vitro.
    Brain Res. 1981 Feb 23;207(1):109-27 PMID: 6258725
  27. Cholinergic excitation of mammalian hippocampal pyramidal cells.
    Brain Res. 1982 Oct 14;249(2):315-31 PMID: 6291715
  28. The action of norepinephrine in the rat hippocampus: intracellular studies in the slice preparation.
    Brain Res. 1981 Feb 9;206(1):107-28 PMID: 6258720
  29. Multiple action of acetylcholine at a muscarinic receptor studied in the rat hippocampal slice.
    Brain Res. 1982 Aug 19;246(1):77-87 PMID: 6289975
  30. The mode of action of antagonists of the excitatory response to acetylcholine in Aplysia neurones.
    J Physiol. 1978 May;278:207-35 PMID: 671288
  31. Histamine produces a Ca2+-sensitive depolarization of hippocampal pyramidal cells in vitro.
    Neurosci Lett. 1980 Aug;19(1):67-71 PMID: 6302594
  32. Minireview: histamine receptors in brain.
    Life Sci. 1979 Sep 11;25(11):895-911 PMID: 41990
  33. Multiple actions of acetylcholine on hippocampal pyramidal cells in organotypic explant cultures.
    Neuroscience. 1982 May;7(5):1243-56 PMID: 6125915
  34. Activators of cyclic adenosine 3':5'-monophosphate accumulation in rat hippocampal slices: action of vasoactive intestinal peptide (VIP).
    J Neurosci. 1983 Dec;3(12):2487-93 PMID: 6317811
  35. Histamine actions on activity of cultured hypothalamic neurons: evidence for mediation by H1- and H2-histamine receptors.
    Brain Res. 1981 Jan;227(1):89-101 PMID: 6258751
  36. Dopamine modulates a Ca2+-activated potassium conductance in mammalian hippocampal pyramidal cells.
    Nature. 1982 May 6;297(5861):76-9 PMID: 6280074
  37. Central actions of histamine: microelectrophoretic studies.
    Brain Res. 1977 Feb 18;122(2):269-79 PMID: 837232
  38. Pharmacological specificity of brain histamine H2-receptors differs in intact cells and cell-free preparations.
    Nature. 1980 Oct 9;287(5782):548-51 PMID: 6106900
  39. The action of 5-hydroxytryptamine on neuronal membranes and synaptic transmission in area CA1 of the hippocampus in vitro.
    Brain Res. 1980 Sep 15;197(1):83-94 PMID: 6249462
  40. Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission.
    Nature. 1982 Dec 2;300(5891):448-50 PMID: 6292731
Article Info
Journal
Pflugers Archiv : European journal of physiology
Abbr.
Pflugers Arch
ISSN
0031-6768
DOI
10.1007/BF00670532
Published
1984-01-00
Pages
28-33
Language
English
Region
Germany
NLM ID
0154720
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00670532 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2